Haloperidol decanoate explained

Haloperidol decanoate, sold under the brand name Haldol Decanoate among others, is a typical antipsychotic which is used in the treatment of schizophrenia.^{[1] [2] [3] [4]} It is administered by injection into muscle at a dose of 100 to 200 mg once every 4 weeks or monthly.^{[5] [6] [7]} The dorsogluteal site is recommended. A 3.75-cm (1.5-inch), 21-gauge needle is generally used, but obese individuals may require a 6.5-cm (2.5-inch) needle to ensure that the drug is indeed injected intramuscularly and not subcutaneously. Haloperidol decanoate is provided in the form of 50 or 100 mg/mL oil solution of sesame oil and benzyl alcohol in ampoules or pre-filled syringes.^[8] Its elimination half-life after multiple doses is 21 days.^{[9] [10]} The medication is marketed in many countries throughout the world.^[11]

See also

• List of antipsychotics § Antipsychotic esters

Notes and References

1. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 619–.
2. Book: Index Nominum 2000: International Drug Directory. 2000. Taylor & Francis. 978-3-88763-075-1. 509–.
3. Book: Kleemann A, Engel J, Kutscher B, Reichert D . Haloperidol decanoate . Pharmaceutical Substances: Syntheses, Patents and Applications of the most relevant APIs . 5th . 2009 . https://books.google.com/books?id=fO2IAwAAQBAJ&pg=PT1376 . Thieme . 978-3-13-179525-0 . 1376–.
4. Book: Morton IK, Hall JM . Concise Dictionary of Pharmacological Agents: Properties and Synonyms. 6 December 2012. Springer Science & Business Media. 978-94-011-4439-1. 139–.
5. Book: Pagliaro LA, Pagliaro AM . Psychologists' Psychotropic Drug Reference. 1999. Psychology Press. 978-0-87630-964-3. 260–.
6. Book: Wyatt RJ, Chew RH . Wyatt's Practical Psychiatric Practice: Forms and Protocols for Clinical Use. 20 May 2008. American Psychiatric Pub. 978-1-58562-687-8. 142–.
7. Book: Fortinash KM, Worret PA . Psychiatric Mental Health Nursing - E-Book. 13 June 2014. Elsevier Health Sciences. 978-0-323-29327-3. 572–.
8. Book: Lee M, Desai A . Gibaldi's Drug Delivery Systems in Pharmaceutical Care. 2007. ASHP. 978-1-58528-136-7. 281–.
9. Davis JM, Matalon L, Watanabe MD, Blake L, Metalon L . Depot antipsychotic drugs. Place in therapy . Drugs . 47 . 5 . 741–773 . May 1994 . 7520856 . 10.2165/00003495-199447050-00004 . 46962898 .
10. Zuidema J, Pieters FA, Duchateau GS . Release and absorption rate aspects of intramuscularly injected pharmaceuticals. International Journal of Pharmaceutics. 47. 1–3. 1988. 1–12. 0378-5173. 10.1016/0378-5173(88)90209-8.
11. Web site: Haloperidol Uses, Side Effects & Warnings.