Halocidin Explained

Halocidin is an antimicrobial peptide isolated from the Halocynthia aurantium species of tunicate.[1] [2] In mouse models, derivative peptides have shown efficacy in the treatment of fungicidal resistant Candida Albacans when used as a mouthwash additive.[3]

Notes and References

  1. Jang WS, Kim KN, Lee YS, Nam MH, Lee IH . Halocidin: a new antimicrobial peptide from hemocytes of the solitary tunicate, Halocynthia aurantium . FEBS Letters . 521 . 1–3 . 81–6 . June 2002 . 12067731 . 10.1016/s0014-5793(02)02827-2 . 45780988 .
  2. Jang WS, Lee SC, Lee YS, Shin YP, Shin KH, Sung BH, Kim BS, Lee SH, Lee IH . 6 . Antimicrobial effect of halocidin-derived peptide in a mouse model of Listeria infection . Antimicrobial Agents and Chemotherapy . 51 . 11 . 4148–4156 . November 2007 . 17846130 . 2151467 . 10.1128/AAC.00635-07 .
  3. Shin SH, Lee YS, Shin YP, Kim B, Kim MH, Chang HR, Jang WS, Lee IH . 6 . Therapeutic efficacy of halocidin-derived peptide HG1 in a mouse model of Candida albicans oral infection . The Journal of Antimicrobial Chemotherapy . 68 . 5 . 1152–1160 . May 2013 . 23302580 . 10.1093/jac/dks513 .

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