Halimadienyl-diphosphate synthase explained

Halimadienyl-diphosphate synthase
Ec Number:	5.5.1.16

Halimadienyl-diphosphate synthase (Rv3377c, halimadienyl diphosphate synthase, tuberculosinol diphosphate synthase, halima-5(6),13-dien-15-yl-diphosphate lyase (cyclizing)) is an enzyme with systematic name halima-5,13-dien-15-yl-diphosphate lyase (decyclizing).^[1] This enzyme catalyses the following chemical reaction

geranylgeranyl diphosphate

\rightleftharpoons tuberculosinyl diphosphate

This enzyme requires Mg²⁺ for activity.

Notes and References

1. Nakano C, Okamura T, Sato T, Dairi T, Hoshino T . Mycobacterium tuberculosis H37Rv3377c encodes the diterpene cyclase for producing the halimane skeleton . Chemical Communications . 8 . 1016–8 . February 2005 . 15719101 . 10.1039/b415346d .