Halicylindramide Explained

Halicylindramides are a group of antifungal peptides. The first compounds of this type, designated halicylindramides A through E, were isolated from sea sponges of the genus Halichondria.[1] [2] More compounds in the family, designated F, G and H, were found in sponges of the genus Petrosia.[3] Halicylindramide A has been synthesized by chemists.[4]

Notes and References

  1. 10.1021/jm00002a015 . Halicylindramides A-C, antifungal and cytotoxic depsipeptides from the marine sponge Halichondria cylindrata . 1995 . Li . Hong-yu . Matsunaga . Shigeki . Fusetani . Nobuhiro . Journal of Medicinal Chemistry . 38 . 2 . 338–343 . 7830276 .
  2. Li . H. . Matsunaga . S. . Fusetani . N. . Halicylindramides D and E, antifungal peptides from the marine sponge Halichondria cylindrata . Journal of Natural Products . February 1996 . 59 . 2 . 163–166 . 10.1021/np9600309 . 8991950 . 0163-3864.
  3. Hahn . Dongyup . Kim . Hiyoung . Yang . Inho . Chin . Jungwook . Hwang . Hoosang . Won . Dong Hwan . Lee . Byoungchan . Nam . Sang-Jip . Ekins . Merrick . Choi . Hyukjae . Kang . Heonjoong . The Halicylindramides, Farnesoid X Receptor Antagonizing Depsipeptides from a Petrosia sp. Marine Sponge Collected in Korea . Journal of Natural Products . 25 March 2016 . 79 . 3 . 499–506 . 10.1021/acs.jnatprod.5b00871. 26821210 .
  4. Seo . Hyunju . Lim . Dongyeol . Total Synthesis of Halicylindramide A . The Journal of Organic Chemistry . 16 January 2009 . 74 . 2 . 906–909 . 10.1021/jo802213q. 19049365 .

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