HYAL3 explained

Hyaluronidase-3 is an enzyme that in humans is encoded by the HYAL3 gene.^{[1] [2]}

This gene encodes a protein which is similar in structure to hyaluronidases. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. However, this protein has not yet been shown to have hyaluronidase activity. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression.

Further reading

• Muzny DM . The DNA sequence, annotation and analysis of human chromosome 3 . Nature . 440 . 7088 . 1194–8 . 2006 . 16641997 . 10.1038/nature04728 . vanc. Scherer SE . Kaul R . 3 . Wang . Jing . Yu . Jun . Sudbrak . Ralf . Buhay . Christian J. . Chen . Rui . Cree . Andrew . 2006Natur.440.1194M . 4413586 . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Junker N, Latini S, Petersen LN, Kristjansen PE . Expression and regulation patterns of hyaluronidases in small cell lung cancer and glioma lines . Oncol. Rep. . 10 . 3 . 609–16 . 2003 . 12684632 . 10.3892/or.10.3.609. 31 January 2024 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Lokeshwar VB . Regulation of hyaluronidase activity by alternative mRNA splicing . J. Biol. Chem. . 277 . 37 . 33654–63 . 2002 . 12084718 . 10.1074/jbc.M203821200 . vanc. Schroeder GL . Carey RI . 3 . Soloway . MS . Iida . N . 8385249 . free .
• Shuttleworth TL . Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3 . J. Biol. Chem. . 277 . 25 . 23008–18 . 2002 . 11929860 . 10.1074/jbc.M108991200 . vanc. Wilson MD . Wicklow BA . 3 . Wilkins . JA . Triggs-Raine . BL . 24252110 . free .
• Triggs-Raine B . Mutations in HYAL1, a member of a tandemly distributed multigene family encoding disparate hyaluronidase activities, cause a newly described lysosomal disorder, mucopolysaccharidosis IX . Proc. Natl. Acad. Sci. U.S.A. . 96 . 11 . 6296–300 . 1999 . 10339581 . 10.1073/pnas.96.11.6296 . 26875 . vanc. Salo TJ . Zhang H . 3 . Wicklow . BA . Natowicz . MR . 1999PNAS...96.6296T . free .

Notes and References

1. Csoka AB, Scherer SW, Stern R . Expression analysis of six paralogous human hyaluronidase genes clustered on chromosomes 3p21 and 7q31 . Genomics . 60 . 3 . 356–61 . Nov 1999 . 10493834 . 10.1006/geno.1999.5876 .
2. Web site: Entrez Gene: HYAL3 hyaluronoglucosaminidase 3.