Onternabez Explained

Onternabez (also known as HU-308, HU308, PPP-003, and ARDS-003) is a synthetic cannabinoid that acts as a potent cannabinoid agonist. It is highly selective for the cannabinoid-2 receptor (CB₂ receptor) subtype, with a selectivity more than 5,000 times greater for the CB₂ receptor than the CB₁ receptor.^{[1] [2] [3]} The synthesis and characterization of onternabez took place in the laboratory of Raphael Mechoulam at the Hebrew University of Jerusalem (the HU in HU-308) in the late 1990s. The pinene dimethoxy-DMH-CBD derivative onternabez was identified as a potent peripheral CB₂-selective agonist in in vitro and animal studies in 1990 and 1999.

Legal status

Onternabez is non-psychoactive and not scheduled at the federal level in the United States.^[4] It is a Schedule I controlled substance in the state of Florida making it illegal to buy, sell, or possess there.^[5]

See also

• Cannabidiol dimethyl ether
• Cannabidiol diacetate
• HU-210
• HU-320
• HU-211
• Nabilone
• CP 47,497

Notes and References

1. Mechoulam R, Lander N, Breuer A, Zahalka J . 1990-04-11. Synthesis of the individual, pharmacologically distinct enantiomers of a tetrahydrocannabinol derivative. Tetrahedron Asymmetry. 1. 5. en. 315–318. 10.1016/S0957-4166(00)86322-3. free.
2. Hanus L, Breuer A, Tchilibon S, Shiloah S, Goldenberg D, Horowitz M, Pertwee RG, Ross RA, Mechoulam R, Fride E . 6 . HU-308: a specific agonist for CB(2), a peripheral cannabinoid receptor . Proceedings of the National Academy of Sciences of the United States of America . 96 . 25 . 14228–14233 . December 1999 . 10588688 . 24419 . 10.1073/pnas.96.25.14228 . free . 1999PNAS...9614228H .
3. Web site: Properties of HU-308 ~ Formula C27H42O3 . Pitt Quantum Repository . University of Pittsburgh Department of Chemistry.
4. Web site: 21 CFR — Schedules of controlled substances §1308.11 Schedule I. . 2014-12-17 . 2009-08-27 . https://web.archive.org/web/20090827043725/http://www.deadiversion.usdoj.gov/21cfr/cfr/1308/1308_11.htm . dead .
5. Web site: Chapter 893 - Drug abuse prevention and control . Florida Statutes .