HTATIP2 explained

Oxidoreductase HTATIP2 is an enzyme that in humans is encoded by the HTATIP2 gene.^{[1] [2] [3] [4]} It may be a metastasis suppressor.

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Baker ME . TIP30, a cofactor for HIV-1 Tat-activated transcription, is homologous to short-chain dehydrogenases/reductases . Curr. Biol. . 9 . 13 . R471 . 1999 . 10395547 . 10.1016/S0960-9822(99)80297-8 . 7740085 . free .
• Whitman S, Wang X, Shalaby R, Shtivelman E . Alternatively spliced products CC3 and TC3 have opposing effects on apoptosis . Mol. Cell. Biol. . 20 . 2 . 583–93 . 2000 . 10611237 . 85138 . 10.1128/MCB.20.2.583-593.2000 .
• Xiao H, Palhan V, Yang Y, Roeder RG . TIP30 has an intrinsic kinase activity required for up-regulation of a subset of apoptotic genes . EMBO J. . 19 . 5 . 956–63 . 2000 . 10698937 . 305635 . 10.1093/emboj/19.5.956 .
• Baker ME, Yan L, Pear MR . Three-dimensional model of human TIP30, a coactivator for HIV-1 Tat-activated transcription, and CC3, a protein associated with metastasis suppression . Cell. Mol. Life Sci. . 57 . 5 . 851–8 . 2000 . 10892349 . 10.1007/s000180050047 . 25141732 . free . 11147082 .
• NicAmhlaoibh R, Shtivelman E . Metastasis suppressor CC3 inhibits angiogenic properties of tumor cells in vitro . Oncogene . 20 . 2 . 270–5 . 2001 . 11313954 . 10.1038/sj.onc.1204075 . free .
• Ito M, Jiang C, Krumm K, Zhang X, Pecha J, Zhao J, Guo Y, Roeder RG, Xiao H . TIP30 deficiency increases susceptibility to tumorigenesis . Cancer Res. . 63 . 24 . 8763–7 . 2004 . 14695192 .
• Jiang C, Ito M, Piening V, Bruck K, Roeder RG, Xiao H . TIP30 interacts with an estrogen receptor alpha-interacting coactivator CIA and regulates c-myc transcription . J. Biol. Chem. . 279 . 26 . 27781–9 . 2004 . 15073177 . 10.1074/jbc.M401809200 . free .
• Tsutsumi S, Kamata N, Vokes TJ, Maruoka Y, Nakakuki K, Enomoto S, Omura K, Amagasa T, Nagayama M, Saito-Ohara F, Inazawa J, Moritani M, Yamaoka T, Inoue H, Itakura M . The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD) . Am. J. Hum. Genet. . 74 . 6 . 1255–61 . 2004 . 15124103 . 1182089 . 10.1086/421527 .
• King FW, Shtivelman E . Inhibition of nuclear import by the proapoptotic protein CC3 . Mol. Cell. Biol. . 24 . 16 . 7091–101 . 2004 . 15282309 . 479715 . 10.1128/MCB.24.16.7091-7101.2004 .
• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S . Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions . Genome Res. . 14 . 9 . 1711–8 . 2004 . 15342556 . 515316 . 10.1101/gr.2435604 .
• Sun L, Feng S, Reséndiz JC, Lu X, Durante W, Kroll MH . Role of the Pyk2-MAP kinase-cPLA2 signaling pathway in shear-dependent platelet aggregation . Annals of Biomedical Engineering . 32 . 9 . 1193–201 . 2005 . 15493507 . 10.1114/B:ABME.0000039353.97347.28 . 31410967 .
• Shi M, Zhang X, Wang P, Zhang HW, Zhang BH, Wu MC . TIP30 regulates apoptosis-related genes in its apoptotic signal transduction pathway . World J. Gastroenterol. . 11 . 2 . 221–7 . 2005 . 15633220 . 4205406 . 10.3748/wjg.v11.i2.221 . free .
• El Omari K, Bird LE, Nichols CE, Ren J, Stammers DK . Crystal structure of CC3 (TIP30): implications for its role as a tumor suppressor . J. Biol. Chem. . 280 . 18 . 18229–36 . 2005 . 15728189 . 10.1074/jbc.M501113200 . free .
• Caldwell RL, Lane KB, Shepherd VL . HIV-1 Tat interaction with cyclin T1 represses mannose receptor and the bone morphogenetic protein receptor-2 transcription . Arch. Biochem. Biophys. . 449 . 1–2 . 27–33 . 2006 . 16615932 . 10.1016/j.abb.2006.02.020 .

Notes and References

1. Xiao H, Tao Y, Greenblatt J, Roeder RG . A cofactor, TIP30, specifically enhances HIV-1 Tat-activated transcription . Proc Natl Acad Sci U S A . 95 . 5 . 2146–51 . Apr 1998 . 9482853 . 19278 . 10.1073/pnas.95.5.2146 . 1998PNAS...95.2146X . free .
2. Shtivelman E . A link between metastasis and resistance to apoptosis of variant small cell lung carcinoma . Oncogene . 14 . 18 . 2167–73 . Jun 1997 . 9174052 . 10.1038/sj.onc.1201059 . free .
3. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jörnvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U . The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative . Chem Biol Interact . 178 . 1–3 . 94–8 . Feb 2009 . 19027726 . 2896744 . 10.1016/j.cbi.2008.10.040 . 2009CBI...178...94P .
4. Web site: Entrez Gene: HTATIP2 HIV-1 Tat interactive protein 2, 30kDa.