HSPH1 explained

Heat shock protein 105 kDa is a protein that in humans is encoded by the HSPH1 gene.^{[1] [2] [3]}

Interactions

HSPH1 has been shown to interact with Cofilin 1.^[4]

Further reading

• Dawson SJ, White LA . Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. . J. Infect. . 24 . 3 . 317–20 . 1992 . 1602151 . 10.1016/S0163-4453(05)80037-4 .
• Nagase T, Seki N, Ishikawa K, etal . Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. . DNA Res. . 3 . 5 . 321–9, 341–54 . 1997 . 9039502 . 10.1093/dnares/3.5.321 . free .
• Hatayama T, Yasuda K, Yasuda K . Association of HSP105 with HSC70 in high molecular mass complexes in mouse FM3A cells. . Biochem. Biophys. Res. Commun. . 248 . 2 . 395–401 . 1998 . 9675148 . 10.1006/bbrc.1998.8979 .
• Ishihara K, Yasuda K, Hatayama T . Phosphorylation of the 105-kDa heat shock proteins, HSP105alpha and HSP105beta, by casein kinase II. . Biochem. Biophys. Res. Commun. . 270 . 3 . 927–31 . 2000 . 10772927 . 10.1006/bbrc.2000.2541 .
• Hylander BL, Chen X, Graf PC, Subjeck JR . The distribution and localization of hsp110 in brain. . Brain Res. . 869 . 1–2 . 49–55 . 2000 . 10865058 . 10.1016/S0006-8993(00)02346-5 . 7179171 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ishihara K, Yamagishi N, Hatayama T . Protein kinase CK2 phosphorylates Hsp105 alpha at Ser509 and modulates its function . Biochem. J. . 371 . Pt 3 . 917–25 . 2003 . 12558502 . 10.1042/BJ20021331 . 1223342 .
• Saito Y, Yamagishi N, Ishihara K, Hatayama T . Identification of alpha-tubulin as an hsp105alpha-binding protein by the yeast two-hybrid system . Exp. Cell Res. . 286 . 2 . 233–40 . 2003 . 12749852 . 10.1016/S0014-4827(03)00054-5 .
• Chen WF, Huang MH, Tzang CH, etal . Inhibitory actions of genistein in human breast cancer (MCF-7) cells . Biochim. Biophys. Acta . 1638 . 2 . 187–96 . 2003 . 12853125 . 10.1016/s0925-4439(03)00082-6 . free .
• Kai M, Nakatsura T, Egami H, etal . Heat shock protein 105 is overexpressed in a variety of human tumors . Oncol. Rep. . 10 . 6 . 1777–82 . 2004 . 14534695 . 10.3892/or.10.6.1777.
• Piechotta K, Garbarini N, England R, Delpire E . Characterization of the interaction of the stress kinase SPAK with the Na⁺-K⁺-2Cl⁻ cotransporter in the nervous system: evidence for a scaffolding role of the kinase . J. Biol. Chem. . 278 . 52 . 52848–56 . 2004 . 14563843 . 10.1074/jbc.M309436200 . free .
• Saito Y, Doi K, Yamagishi N, etal . Screening of Hsp105alpha-binding proteins using yeast and bacterial two-hybrid systems . Biochem. Biophys. Res. Commun. . 314 . 2 . 396–402 . 2004 . 14733918 . 10.1016/j.bbrc.2003.12.108 .
• Dunham A, Matthews LH, Burton J, etal . The DNA sequence and analysis of human chromosome 13 . Nature . 428 . 6982 . 522–8 . 2004 . 15057823 . 10.1038/nature02379 . 2665288 . 2004Natur.428..522D .
• Ballif BA, Villén J, Beausoleil SA, etal . Phosphoproteomic analysis of the developing mouse brain . Mol. Cell. Proteomics . 3 . 11 . 1093–101 . 2005 . 15345747 . 10.1074/mcp.M400085-MCP200 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Kim JE, Tannenbaum SR, White FM . Global phosphoproteome of HT-29 human colon adenocarcinoma cells . J. Proteome Res. . 4 . 4 . 1339–46 . 2005 . 16083285 . 10.1021/pr050048h .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Miyazaki M, Nakatsura T, Yokomine K, etal . DNA vaccination of HSP105 leads to tumor rejection of colorectal cancer and melanoma in mice through activation of both CD4 T cells and CD8 T cells . Cancer Sci. . 96 . 10 . 695–705 . 2005 . 16232202 . 10.1111/j.1349-7006.2005.00093.x . 23598038 . free . 11158364 .

Notes and References

1. Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, Tureci O, Sahin U, Pfreundschuh M, Old LJ . Characterization of human colon cancer antigens recognized by autologous antibodies . Int J Cancer . 76 . 5 . 652–8 . Jun 1998 . 9610721 . 10.1002/(SICI)1097-0215(19980529)76:5<652::AID-IJC7>3.0.CO;2-P . 916155 .
2. Ishihara K, Yasuda K, Hatayama T . Molecular cloning, expression and localization of human 105 kDa heat shock protein, hsp105 . Biochim Biophys Acta . 1444 . 1 . 138–42 . Mar 1999 . 9931472 . 10.1016/s0167-4781(98)00254-1.
3. Web site: Entrez Gene: HSPH1 heat shock 105kDa/110kDa protein 1.
4. Saito . Youhei . Doi Kazuya . Yamagishi Nobuyuki . Ishihara Keiichi . Hatayama Takumi . Feb 2004 . Screening of Hsp105alpha-binding proteins using yeast and bacterial two-hybrid systems . Biochem. Biophys. Res. Commun. . 314 . 2 . 396–402 . 0006-291X. 14733918 . 10.1016/j.bbrc.2003.12.108 .