HSPB7 explained

Heat Shock Protein Family B (small) member 7 (HSPB7) in humans is a protein encoded by a gene of the same name with four exons that is located on chromosome 1p36.13.[1] ,.[2] HSPB7 contains 170 amino acids and has a molecular weight of 18,611Da.[3] HSPB7 is a member of human small heat shock protein (HSPB) family, which contains eleven family members of chaperone proteins.[4] HSPB7 and its gene pair SRARP are located 5 kb apart on the opposite strands of chromosome 1p36.13.[5]

Expression and molecular function

HSPB7 is widely expressed throughout the body and its highest expression is observed in the cardiac tissue ,.[6] HSPB protein family, including HSPB7, act protectively on aggregation of several proteins containing an extended polyglutamine (polyQ) stretch that are linked to a variety of neurodegenerative diseases.[7] Among these proteins, HSPB7 is the most potent polyQ aggregation suppressor within the HSPB family of chaperones. In addition, HSPB7 protein contains a HSP20 domain and strongly interacts with the chaperone protein 14-3-3. An interaction with the 14-3-3 protein is a common molecular feature between HSPB7 and SRARP proteins ,[8]

Role in cardiomyopathy and Cancer

HSPB7 has cardiac protective functions and mutations in this gene leads to cardiomyopathies. It has been suggested that HSPB7 cardioprotective function is mediated by facilitating sarcomeric proteostasis.[9] Furthermore, HSPB7 is widely inactivated in malignancies by copy-number loss and epigenetic silencing and the overexpression of this protein results in a tumor suppressor function in multiple cancer cell lines,.[10] The overexpression of HSPB7 and its gene pair SRARP lead to a reduction in the relative phosphorylation and/or expression of Akt and ERK in cancer cells. In addition, it has been suggested that HSBP7 is regulated by p53 tumor suppressor in renal cell carcinoma.

Approved Symbol HSPB7
Approved Name Heat shock protein family B (small) member 7
HGNC ID HGNC:5249
Previous name heat shock 27kD protein family, member 7 (cardiovascular)
Alias Symbols cvHSP
Chromosome location 1p36.13
EnsemblENSG00000173641
UniProtQ9UBY9
NCBI Gene27129
RefSeq NM_014424
UCSC uc001axo.2
Protein Sequence HSPB7 Protein Sequence (Ensembl)
Wikidata Q18038659
PubMed HSPB7 PubMed References

Notes and References

  1. Web site: HSPB7. HUGO Gene Nomenclature Committee.
  2. Web site: HSPB7 heat shock protein family B (small) member 7 [Homo sapiens (human)]]. The National Center for Biotechnology Information.
  3. Web site: HSPB7_HUMAN. UniProt.
  4. Vos MJ, Kanon B, Kampinga HH . HSPB7 is a SC35 speckle resident small heat shock protein . Biochimica et Biophysica Acta (BBA) - Molecular Cell Research . 1793 . 8 . 1343–53 . August 2009 . 19464326 . 10.1016/j.bbamcr.2009.05.005 . free .
  5. Naderi A . SRARP and HSPB7 are epigenetically regulated gene pairs that function as tumor suppressors and predict clinical outcome in malignancies . Molecular Oncology . 12 . 5 . 724–755 . May 2018 . 29577611 . 5928383 . 10.1002/1878-0261.12195 .
  6. Wu T, Mu Y, Bogomolovas J, Fang X, Veevers J, Nowak RB, Pappas CT, Gregorio CC, Evans SM, Fowler VM, Chen J . 6 . HSPB7 is indispensable for heart development by modulating actin filament assembly . Proceedings of the National Academy of Sciences of the United States of America . 114 . 45 . 11956–11961 . November 2017 . 29078393 . 5692592 . 10.1073/pnas.1713763114 . 2017PNAS..11411956W . free .
  7. Vos MJ, Zijlstra MP, Kanon B, van Waarde-Verhagen MA, Brunt ER, Oosterveld-Hut HM, Carra S, Sibon OC, Kampinga HH . 6 . HSPB7 is the most potent polyQ aggregation suppressor within the HSPB family of molecular chaperones . Human Molecular Genetics . 19 . 23 . 4677–93 . December 2010 . 20843828 . 10.1093/hmg/ddq398 . free .
  8. Naderi A . C1orf64 is a novel androgen receptor target gene and coregulator that interacts with 14-3-3 protein in breast cancer . Oncotarget . 8 . 34 . 57907–57933 . August 2017 . 28915724 . 5593696 . 10.18632/oncotarget.17826 .
  9. Mercer EJ, Lin YF, Cohen-Gould L, Evans T . Hspb7 is a cardioprotective chaperone facilitating sarcomeric proteostasis . Developmental Biology . 435 . 1 . 41–55 . March 2018 . 29331499 . 5818303 . 10.1016/j.ydbio.2018.01.005 .
  10. Lin J, Deng Z, Tanikawa C, Shuin T, Miki T, Matsuda K, Nakamura Y . Downregulation of the tumor suppressor HSPB7, involved in the p53 pathway, in renal cell carcinoma by hypermethylation . International Journal of Oncology . 44 . 5 . 1490–8 . May 2014 . 24585183 . 4027944 . 10.3892/ijo.2014.2314 .

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "HSPB7".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.