HSPA2 explained

Heat shock-related 70 kDa protein 2 is a protein that in humans is encoded by the HSPA2 gene.^[1]

Further reading

• Schwab CG, Bozak CK, Whitehouse NL, Olson VM . Amino acid limitation and flow to the duodenum at four stages of lactation. 2. Extent of lysine limitation. . J. Dairy Sci. . 75 . 12 . 3503–18 . 1993 . 1474216 . 10.3168/jds.S0022-0302(92)78126-0 . free .
• Dworniczak B, Mirault ME . Structure and expression of a human gene coding for a 71 kd heat shock 'cognate' protein. . Nucleic Acids Res. . 15 . 13 . 5181–97 . 1987 . 3037489 . 10.1093/nar/15.13.5181 . 305955 .
• Bonnycastle LL, Yu CE, Hunt CR, etal . Cloning, sequencing, and mapping of the human chromosome 14 heat shock protein gene (HSPA2). . Genomics . 23 . 1 . 85–93 . 1995 . 7829106 . 10.1006/geno.1994.1462 .
• Roux AF, Nguyen VT, Squire JA, Cox DW . A heat shock gene at 14q22: mapping and expression. . Hum. Mol. Genet. . 3 . 10 . 1819–22 . 1995 . 7849706 . 10.1093/hmg/3.10.1819 .
• Furlini G, Vignoli M, Re MC, etal . Human immunodeficiency virus type 1 interaction with the membrane of CD4+ cells induces the synthesis and nuclear translocation of 70K heat shock protein. . J. Gen. Virol. . 75 . 1 . 193–9 . 1994 . 7906708 . 10.1099/0022-1317-75-1-193 . free .
• Allen JW, Dix DJ, Collins BW, etal . HSP70-2 is part of the synaptonemal complex in mouse and hamster spermatocytes. . Chromosoma . 104 . 6 . 414–21 . 1996 . 8601336 . 10.1007/BF00352265 . 7244472 .
• Dix DJ, Allen JW, Collins BW, etal . Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility. . Proc. Natl. Acad. Sci. U.S.A. . 93 . 8 . 3264–8 . 1996 . 8622925 . 10.1073/pnas.93.8.3264 . 39594 . 1996PNAS...93.3264D . free .
• Zhu D, Dix DJ, Eddy EM . HSP70-2 is required for CDC2 kinase activity in meiosis I of mouse spermatocytes. . Development . 124 . 15 . 3007–14 . 1997 . 10.1242/dev.124.15.3007 . 9247342 .
• O'Keeffe B, Fong Y, Chen D, etal . Requirement for a kinase-specific chaperone pathway in the production of a Cdk9/cyclin T1 heterodimer responsible for P-TEFb-mediated tat stimulation of HIV-1 transcription. . J. Biol. Chem. . 275 . 1 . 279–87 . 2000 . 10617616 . 10.1074/jbc.275.1.279 . free.
• Agostini I, Popov S, Li J, etal . Heat-shock protein 70 can replace viral protein R of HIV-1 during nuclear import of the viral preintegration complex. . Exp. Cell Res. . 259 . 2 . 398–403 . 2000 . 10964507 . 10.1006/excr.2000.4992 .
• Andersen JS, Lyon CE, Fox AH, etal . Directed proteomic analysis of the human nucleolus. . Curr. Biol. . 12 . 1 . 1–11 . 2002 . 11790298 . 10.1016/S0960-9822(01)00650-9 . free . 2002CBio...12....1A .
• Gurer C, Cimarelli A, Luban J . Specific incorporation of heat shock protein 70 family members into primate lentiviral virions. . J. Virol. . 76 . 9 . 4666–70 . 2002 . 11932435 . 10.1128/JVI.76.9.4666-4670.2002 . 155079 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Shin BK, Wang H, Yim AM, etal . Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function. . J. Biol. Chem. . 278 . 9 . 7607–16 . 2003 . 12493773 . 10.1074/jbc.M210455200 . free .
• Lim MC, Brooke SM, Sapolsky RM . gp120 neurotoxicity fails to induce heat shock defenses, while the over expression of hsp70 protects against gp120. . Brain Res. Bull. . 61 . 2 . 183–8 . 2003 . 12832005 . 10.1016/S0361-9230(03)00113-8 . 35451084 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Bouwmeester T, Bauch A, Ruffner H, etal . A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. . Nat. Cell Biol. . 6 . 2 . 97–105 . 2004 . 14743216 . 10.1038/ncb1086 . 11683986 .
• Brandenberger R, Wei H, Zhang S, etal . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. . Nat. Biotechnol. . 22 . 6 . 707–16 . 2005 . 15146197 . 10.1038/nbt971 . 27764390 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Web site: Entrez Gene: HSPA2 heat shock 70kDa protein 2.