HSPA13 explained

Heat shock 70 kDa protein 13 is a protein that in humans is encoded by the HSPA13 gene.^{[1] [2]}

The protein encoded by this gene is a member of the heat shock protein 70 family and is found associated with endoplasmic reticulum. Members of this protein family play a role in the processing of cytosolic and secretory proteins, as well as in the removal of denatured or incorrectly folded proteins. The encoded protein contains an ATPase domain and has been shown to associate with a ubiquitin-like protein.

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Otterson GA, Flynn GC, Kratzke RA, etal . Stch encodes the 'ATPase core' of a microsomal stress 70 protein. . EMBO J. . 13 . 5 . 1216–25 . 1994 . 8131751 . 10.1002/j.1460-2075.1994.tb06371.x. 394931 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Hillier LD, Lennon G, Becker M, etal . Generation and analysis of 280,000 human expressed sequence tags. . Genome Res. . 6 . 9 . 807–28 . 1997 . 8889549 . 10.1101/gr.6.9.807 . free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Kaye FJ, Modi S, Ivanovska I, etal . A family of ubiquitin-like proteins binds the ATPase domain of Hsp70-like Stch. . FEBS Lett. . 467 . 2–3 . 348–55 . 2000 . 10675567 . 10.1016/S0014-5793(00)01135-2 . 11514284 . free .
• Hattori M, Fujiyama A, Taylor TD, etal . The DNA sequence of human chromosome 21. . Nature . 405 . 6784 . 311–9 . 2000 . 10830953 . 10.1038/35012518 . 2000Natur.405..311H . free .
• Wistow G, Bernstein SL, Wyatt MK, etal . Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants. . Mol. Vis. . 8 . 205–20 . 2002 . 12107410 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Aoki M, Yamamoto K, Ohyama S, etal . A genetic variant in the gene encoding the stress70 protein chaperone family member STCH is associated with gastric cancer in the Japanese population. . Biochem. Biophys. Res. Commun. . 335 . 2 . 566–74 . 2005 . 16087163 . 10.1016/j.bbrc.2005.07.110 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Brodsky G, Otterson GA, Parry BB, Hart I, Patterson D, Kaye FJ . Localization of STCH to human chromosome 21q11.1 . Genomics . 30 . 3 . 627–8 . Feb 1997 . 8825657 . 10.1006/geno.1995.1291 .
2. Web site: HSPA13 heat shock protein family A (Hsp70) member 13 [Homo sapiens (human) ]].