HSF2 explained

Heat shock factor protein 2 is a protein that in humans is encoded by the HSF2 gene.^{[1] [2]}

Function

HSF2, as well as the related gene HSF1, encodes a protein that binds specifically to the heat-shock element and has homology to HSFs of other species. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Although the names HSF1 and HSF2 were chosen for historical reasons, these peptides should be referred to as heat-shock transcription factors.^[2]

Interactions

HSF2 has been shown to interact with Nucleoporin 62^[3] and HSF1.^[4]

See also

• Heat shock factor

Further reading

• Walsh D, Li Z, Wu Y, Nagata K . Heat shock and the role of the HSPs during neural plate induction in early mammalian CNS and brain development. . Cell. Mol. Life Sci. . 53 . 2 . 198–211 . 1997 . 9118008 . 10.1007/PL00000592 . 32425345 . 11147247 .
• Sarge KD, Zimarino V, Holm K, Wu C, Morimoto RI . Cloning and characterization of two mouse heat shock factors with distinct inducible and constitutive DNA-binding ability. . Genes Dev. . 5 . 10 . 1902–11 . 1991 . 1717345 . 10.1101/gad.5.10.1902 . free .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Sheldon LA, Kingston RE . Hydrophobic coiled-coil domains regulate the subcellular localization of human heat shock factor 2. . Genes Dev. . 7 . 8 . 1549–58 . 1993 . 8339932 . 10.1101/gad.7.8.1549 . free .
• Yoshima T, Yura T, Yanagi H . The trimerization domain of human heat shock factor 2 is able to interact with nucleoporin p62. . Biochem. Biophys. Res. Commun. . 240 . 1 . 228–33 . 1997 . 9367915 . 10.1006/bbrc.1997.7662 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Yoshima T, Yura T, Yanagi H . Novel testis-specific protein that interacts with heat shock factor 2. . Gene . 214 . 1–2 . 139–46 . 1998 . 9651507 . 10.1016/S0378-1119(98)00208-X .
• Hong Y, Sarge KD . Regulation of protein phosphatase 2A activity by heat shock transcription factor 2. . J. Biol. Chem. . 274 . 19 . 12967–70 . 1999 . 10224043 . 10.1074/jbc.274.19.12967 . free .
• Goodson ML, Hong Y, Rogers R, Matunis MJ, Park-Sarge OK, Sarge KD . Sumo-1 modification regulates the DNA binding activity of heat shock transcription factor 2, a promyelocytic leukemia nuclear body associated transcription factor. . J. Biol. Chem. . 276 . 21 . 18513–8 . 2001 . 11278381 . 10.1074/jbc.M008066200 . free .
• Nykänen P, Alastalo TP, Ahlskog J, Horelli-Kuitunen N, Pirkkala L, Sistonen L . Genomic organization and promoter analysis of the human heat shock factor 2 gene. . Cell Stress & Chaperones . 6 . 4 . 377–85 . 2002 . 10.1379/1466-1268(2001)006<0377:goapao>2.0.co;2 . 2024-04-02 . 11795475 . 434421 .
• He H, Soncin F, Grammatikakis N, Li Y, Siganou A, Gong J, Brown SA, Kingston RE, Calderwood SK . Elevated expression of heat shock factor (HSF) 2A stimulates HSF1-induced transcription during stress. . J. Biol. Chem. . 278 . 37 . 35465–75 . 2003 . 12813038 . 10.1074/jbc.M304663200 . free .
• Alastalo TP, Hellesuo M, Sandqvist A, Hietakangas V, Kallio M, Sistonen L . Formation of nuclear stress granules involves HSF2 and coincides with the nucleolar localization of Hsp70. . J. Cell Sci. . 116 . Pt 17 . 3557–70 . 2004 . 12865437 . 10.1242/jcs.00671 . free .
• Roccisana JL, Kawanabe N, Kajiya H, Koide M, Roodman GD, Reddy SV . Functional role for heat shock factors in the transcriptional regulation of human RANK ligand gene expression in stromal/osteoblast cells. . J. Biol. Chem. . 279 . 11 . 10500–7 . 2004 . 14699143 . 10.1074/jbc.M303727200 . free .
• Xing H, Wilkerson DC, Mayhew CN, Lubert EJ, Skaggs HS, Goodson ML, Hong Y, Park-Sarge OK, Sarge KD . Mechanism of hsp70i gene bookmarking. . Science . 307 . 5708 . 421–3 . 2005 . 15662014 . 10.1126/science.1106478 . 2005Sci...307..421X . 37132180 .
• Anckar J, Hietakangas V, Denessiouk K, Thiele DJ, Johnson MS, Sistonen L . Inhibition of DNA binding by differential sumoylation of heat shock factors. . Mol. Cell. Biol. . 26 . 3 . 955–64 . 2006 . 16428449 . 1347039 . 10.1128/MCB.26.3.955-964.2006 .

Notes and References

1. Schuetz TJ, Gallo GJ, Sheldon L, Tempst P, Kingston RE . Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans . Proc Natl Acad Sci U S A . 88 . 16 . 6911–5 . Sep 1991 . 1871106 . 52203 . 10.1073/pnas.88.16.6911 . 1991PNAS...88.6911S . free .
2. Web site: Entrez Gene: HSF2 heat shock transcription factor 2.
3. Yoshima T, Yura T, Yanagi H . The trimerization domain of human heat shock factor 2 is able to interact with nucleoporin p62 . Biochem. Biophys. Res. Commun. . 240 . 1 . 228–33 . Nov 1997 . 9367915 . 10.1006/bbrc.1997.7662 .
4. He H, Soncin F, Grammatikakis N, Li Y, Siganou A, Gong J, Brown SA, Kingston RE, Calderwood SK . Elevated expression of heat shock factor (HSF) 2A stimulates HSF1-induced transcription during stress . J. Biol. Chem. . 278 . 37 . 35465–75 . Sep 2003 . 12813038 . 10.1074/jbc.M304663200 . free .