HSD17B7 explained

3-keto-steroid reductase is an enzyme that in humans is encoded by the HSD17B7 gene.^{[1] [2] [3] [4]}

The 17-beta-hydroxysteroid dehydrogenase enzyme (EC 1.1.1.62) oxidizes or reduces estrogens and androgens in mammals and regulates the biologic potency of these steroids.[supplied by OMIM]^[5]

Further reading

• Mendoza-Hernández G, Rendón JL, Díaz-Zagoya JC . A single step procedure for purification of estradiol 17 beta-dehydrogenase from human placenta. . Biochem. Biophys. Res. Commun. . 126 . 1 . 477–81 . 1985 . 3855619 . 10.1016/0006-291X(85)90630-8 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Törn S, Nokelainen P, Kurkela R, etal . Production, purification, and functional analysis of recombinant human and mouse 17beta-hydroxysteroid dehydrogenase type 7. . Biochem. Biophys. Res. Commun. . 305 . 1 . 37–45 . 2003 . 12732193 . 10.1016/S0006-291X(03)00694-6 .
• Marijanovic Z, Laubner D, Moller G, etal . Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis. . Mol. Endocrinol. . 17 . 9 . 1715–25 . 2004 . 12829805 . 10.1210/me.2002-0436 .
• Clark HF, Gurney AL, Abaya E, etal . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Ohnesorg T, Adamski J . Promoter analyses of human and mouse 17beta-hydroxysteroid dehydrogenase type 7. . J. Steroid Biochem. Mol. Biol. . 94 . 1–3 . 259–61 . 2005 . 15862973 . 10.1016/j.jsbmb.2005.01.012 . 46113625 .
• Ohnesorg T, Adamski J . Analysis of the 5' flanking regions of human and murine HSD17B7: identification of a cholesterol dependent enhancer region. . Mol. Cell. Endocrinol. . 248 . 1–2 . 164–7 . 2006 . 16356630 . 10.1016/j.mce.2005.10.016 . 8896905 .
• Ohnesorg T, Keller B, Hrabé de Angelis M, Adamski J . Transcriptional regulation of human and murine 17beta-hydroxysteroid dehydrogenase type-7 confers its participation in cholesterol biosynthesis. . J. Mol. Endocrinol. . 37 . 1 . 185–97 . 2007 . 16901934 . 10.1677/jme.1.02043 . free .
• Smuc T, Pucelj MR, Sinkovec J, etal . Expression analysis of the genes involved in estradiol and progesterone action in human ovarian endometriosis. . Gynecol. Endocrinol. . 23 . 2 . 105–11 . 2007 . 17454161 . 10.1080/09513590601152219 . 41842764 .
• Guggenberger C, Ilgen D, Adamski J . Functional analysis of cholesterol biosynthesis by RNA interference. . J. Steroid Biochem. Mol. Biol. . 104 . 3–5 . 105–9 . 2007 . 17498944 . 10.1016/j.jsbmb.2007.03.001 . 20838858 .

Notes and References

1. Krazeisen A, Breitling R, Imai K, Fritz S, Moller G, Adamski J . Determination of cDNA, gene structure and chromosomal localization of the novel human 17beta-hydroxysteroid dehydrogenase type 7(1) . FEBS Lett . 460 . 2 . 373–9 . Dec 1999 . 10544267 . 10.1016/S0014-5793(99)01366-6 . 11558347 . free .
2. Peltoketo H, Nokelainen P, Piao YS, Vihko R, Vihko P . Two 17beta-hydroxysteroid dehydrogenases (17HSDs) of estradiol biosynthesis: 17HSD type 1 and type 7 . J Steroid Biochem Mol Biol . 69 . 1–6 . 431–9 . Aug 1999 . 10419022 . 10.1016/S0960-0760(99)00064-3 . 25448122 .
3. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U . The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative . Chem Biol Interact . 178 . 1–3 . 94–8 . Feb 2009 . 19027726 . 2896744. 10.1016/j.cbi.2008.10.040 . 2009CBI...178...94P .
4. Web site: Entrez Gene: HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7.
5. Web site: Entrez Gene: HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7.