HSD17B11 explained

Estradiol 17-beta-dehydrogenase 11 is an enzyme that in humans is encoded by the HSD17B11 gene.^{[1] [2] [3] [4]}

HSD17B11 expression has been linked to higher survival rates for lung cancer patients.^[5]

Further reading

• Li KX, Smith RE, Krozowski ZS . Cloning and expression of a novel tissue specific 17beta-hydroxysteroid dehydrogenase . Endocrine Research . 24 . 3–4 . 663–7 . 1999 . 9888557 . 10.3109/07435809809032667 .
• Book: Haeseleer F, Palczewski K . Short-chain dehydrogenases/Reductases in retina . Vertebrate Phototransduction and the Visual Cycle, Part B . Methods in Enzymology . 316 . 372–83 . 2000 . 10800688 . 10.1016/S0076-6879(00)16736-9 . 978-0-12-182217-0 .
• Hartmann TB, Thiel D, Dummer R, Schadendorf D, Eichmüller S . SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma . The British Journal of Dermatology . 150 . 2 . 252–8 . February 2004 . 14996095 . 10.1111/j.1365-2133.2004.05651.x . 42495130 .
• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T . Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries . DNA Research . 12 . 2 . 117–26 . 2007 . 16303743 . 10.1093/dnares/12.2.117 . free .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Research . 16 . 1 . 55–65 . January 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .

Notes and References

1. Brereton P, Suzuki T, Sasano H, Li K, Duarte C, Obeyesekere V, Haeseleer F, Palczewski K, Smith I, Komesaroff P, Krozowski Z . Pan1b (17betaHSD11)-enzymatic activity and distribution in the lung . Molecular and Cellular Endocrinology . 171 . 1–2 . 111–7 . January 2001 . 11165019 . 10.1016/S0303-7207(00)00417-2 . 54263651 .
2. Chai Z, Brereton P, Suzuki T, Sasano H, Obeyesekere V, Escher G, Saffery R, Fuller P, Enriquez C, Krozowski Z . 17 beta-hydroxysteroid dehydrogenase type XI localizes to human steroidogenic cells . Endocrinology . 144 . 5 . 2084–91 . May 2003 . 12697717 . 10.1210/en.2002-221030 . free .
3. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jörnvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U . The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative . Chemico-Biological Interactions . 178 . 1–3 . 94–8 . March 2009 . 19027726 . 2896744 . 10.1016/j.cbi.2008.10.040 . 2009CBI...178...94P .
4. Web site: Entrez Gene: HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11.
5. Web site: Research update from the MCM team (March 2024). World Community Grid. 14 March 2024. 21 May 2024.