HS3ST3B1 explained

Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 is an enzyme that in humans is encoded by the HS3ST3B1 gene.^{[1] [2]} Heparan sulfate biosynthetic enzymes are key components in generating myriad distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity (HS3ST3A1). The Sulfotransferase domain of this enzyme is highly similar to the same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1 and these two enzymes sulfate an identical disaccharide. This gene is widely expressed, with the most abundant expression in liver and placenta.

Further reading

• Razi N, Lindahl U . Biosynthesis of heparin/heparan sulfate. The D-glucosaminyl 3-O-sulfotransferase reaction: target and inhibitor saccharides . J. Biol. Chem. . 270 . 19 . 11267–75 . 1995 . 7744762 . 10.1074/jbc.270.19.11267 . free .
• Liu J, Shworak NW, Sinaÿ P, etal . Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities . J. Biol. Chem. . 274 . 8 . 5185–92 . 1999 . 9988768 . 10.1074/jbc.274.8.5185 . free.
• Shukla D, Liu J, Blaiklock P, etal . A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry . Cell . 99 . 1 . 13–22 . 1999 . 10520990 . 10.1016/S0092-8674(00)80058-6 . 14139940 . free .
• Salehi LB, Mangino M, De Serio S, etal . Assignment of a locus for autosomal dominant idiopathic scoliosis (IS) to human chromosome 17p11 . Hum. Genet. . 111 . 4–5 . 401–4 . 2002 . 12384783 . 10.1007/s00439-002-0785-4 . 29912776 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Moon AF, Edavettal SC, Krahn JM, etal . Structural analysis of the sulfotransferase (3-o-sulfotransferase isoform 3) involved in the biosynthesis of an entry receptor for herpes simplex virus 1 . J. Biol. Chem. . 279 . 43 . 45185–93 . 2004 . 15304505 . 4114238 . 10.1074/jbc.M405013200 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .

Notes and References

1. Shworak NW, Liu J, Petros LM, Zhang L, Kobayashi M, Copeland NG, Jenkins NA, Rosenberg RD . Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci . J Biol Chem . 274 . 8 . 5170–84 . Mar 1999 . 9988767 . 10.1074/jbc.274.8.5170 . free .
2. Web site: Entrez Gene: HS3ST3B1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1.