HS1BP3 explained

HCLS1 binding protein 3
Hgncid:	24979
Symbol:	HS1BP3
Entrezgene:	64342
Omim:	609359
Refseq:	NM_022460
Uniprot:	Q53T59
Chromosome:	2
Arm:	p
Band:	24.1

HCLS1 binding protein 3 also known as HS1BP3 is a protein which in humans is encoded by the HS1BP3 gene.^{[1] [2]}

Function

The protein encoded by this gene shares similarity with mouse Hs1bp3, an Hcls1-interacting protein that may be involved in lymphocyte activation.^[3]

HS1BP3 binds members of the 14-3-3 protein family, which are highly expressed in motor neurons and Purkinje cells and regulate the Ca²⁺ / calmodulin-dependent protein kinase activation of tyrosine and tryptophan hydroxylase.^[2]

Notes and References

1. Takemoto Y, Furuta M, Sato M, Kubo M, Hashimoto Y . Isolation and characterization of a novel HS1 SH3 domain binding protein, HS1BP3 . Int. Immunol. . 11 . 12 . 1957–64 . December 1999 . 10590261 . 10.1093/intimm/11.12.1957. free .
2. Higgins JJ, Lombardi RQ, Pucilowska J, Jankovic J, Tan EK, Rooney JP . A variant in the HS1-BP3 gene is associated with familial essential tremor . Neurology . 64 . 3 . 417–21 . February 2005 . 15699368 . 1201396 . 10.1212/01.WNL.0000153481.30222.38 .
3. Web site: Entrez Gene: HCLS1 binding protein 3 .