HRC (gene) explained

Sarcoplasmic reticulum histidine-rich calcium-binding protein is a protein that in humans is encoded by the HRC gene.^{[1] [2]}

Function

Histidine-rich calcium-binding protein is a luminal sarcoplasmic reticulum protein of 165 kD identified by its ability to bind low-density lipoprotein with high affinity^[2]

Further reading

• Anderson NL, Anderson NG . The human plasma proteome: history, character, and diagnostic prospects . Molecular & Cellular Proteomics . 1 . 11 . 845–67 . Nov 2002 . 12488461 . 10.1074/mcp.R200007-MCP200 . free .
• Hofmann SL, Brown MS, Lee E, Pathak RK, Anderson RG, Goldstein JL . Purification of a sarcoplasmic reticulum protein that binds Ca2+ and plasma lipoproteins . The Journal of Biological Chemistry . 264 . 14 . 8260–70 . May 1989 . 10.1016/S0021-9258(18)83178-7 . 2498310 . free .
• Ridgeway AG, Petropoulos H, Siu A, Ball JK, Skerjanc IS . Cloning, tissue distribution, subcellular localization and overexpression of murine histidine-rich Ca2+ binding protein . FEBS Letters . 456 . 3 . 399–402 . Aug 1999 . 10462052 . 10.1016/S0014-5793(99)00993-X . 19920072 . free .
• Lee HG, Kang H, Kim DH, Park WJ . Interaction of HRC (histidine-rich Ca(2+)-binding protein) and triadin in the lumen of sarcoplasmic reticulum . The Journal of Biological Chemistry . 276 . 43 . 39533–8 . Oct 2001 . 11504710 . 10.1074/jbc.M010664200 . free .
• Sacchetto R, Damiani E, Turcato F, Nori A, Margreth A . Ca(2+)-dependent interaction of triadin with histidine-rich Ca(2+)-binding protein carboxyl-terminal region . Biochemical and Biophysical Research Communications . 289 . 5 . 1125–34 . Dec 2001 . 11741309 . 10.1006/bbrc.2001.6126 .
• Kim E, Shin DW, Hong CS, Jeong D, Kim DH, Park WJ . Increased Ca2+ storage capacity in the sarcoplasmic reticulum by overexpression of HRC (histidine-rich Ca2+ binding protein) . Biochemical and Biophysical Research Communications . 300 . 1 . 192–6 . Jan 2003 . 12480542 . 10.1016/S0006-291X(02)02829-2 .
• Adkins JN, Varnum SM, Auberry KJ, Moore RJ, Angell NH, Smith RD, Springer DL, Pounds JG . Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry . Molecular & Cellular Proteomics . 1 . 12 . 947–55 . Dec 2002 . 12543931 . 10.1074/mcp.M200066-MCP200 . free .
• Anderson JP, Dodou E, Heidt AB, De Val SJ, Jaehnig EJ, Greene SB, Olson EN, Black BL . HRC is a direct transcriptional target of MEF2 during cardiac, skeletal, and arterial smooth muscle development in vivo . Molecular and Cellular Biology . 24 . 9 . 3757–68 . May 2004 . 15082771 . 387749 . 10.1128/MCB.24.9.3757-3768.2004 .
• Fan GC, Gregory KN, Zhao W, Park WJ, Kranias EG . Regulation of myocardial function by histidine-rich, calcium-binding protein . American Journal of Physiology. Heart and Circulatory Physiology . 287 . 4 . H1705–11 . Oct 2004 . 15191886 . 10.1152/ajpheart.01211.2003 . 15011211 .
• Arvanitis DA, Vafiadaki E, Fan GC, Mitton BA, Gregory KN, Del Monte F, Kontrogianni-Konstantopoulos A, Sanoudou D, Kranias EG . Histidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPase . American Journal of Physiology. Heart and Circulatory Physiology . 293 . 3 . H1581–9 . Sep 2007 . 17526652 . 10.1152/ajpheart.00278.2007 . 12820507 .
• Singh VP, Rubinstein J, Arvanitis DA, Ren X, Gao X, Haghighi K, Gilbert M, Iyer VR, Kim DH, Cho C, Jones K, Lorenz JN, Armstrong CF, Wang HS, Gyorke S, Kranias EG . Abnormal calcium cycling and cardiac arrhythmias associated with the human Ser96Ala genetic variant of histidine-rich calcium-binding protein . Journal of the American Heart Association . 2 . 5 . e000460 . 2013 . 24125847 . 3835262 . 10.1161/JAHA.113.000460 .

Notes and References

1. Hofmann SL, Topham M, Hsieh CL, Francke U . cDNA and genomic cloning of HRC, a human sarcoplasmic reticulum protein, and localization of the gene to human chromosome 19 and mouse chromosome 7 . Genomics . 9 . 4 . 656–69 . Apr 1991 . 2037293 . 10.1016/0888-7543(91)90359-M .
2. Web site: Entrez Gene: HRC histidine rich calcium binding protein.