HRBL explained

Arf-GAP domain and FG repeats-containing protein 2 is a protein that in humans is encoded by the AGFG2 gene.^{[1] [2]}

This gene is a member of the HIV-1 Rev binding protein (HRB) family and encodes a protein with one Arf-GAP zinc finger domain, several phe-gly (FG) motifs, and four asn-pro-phe (NPF) motifs. This protein interacts with Eps15 homology (EH) domains and plays a role in the Rev export pathway, which mediates the nucleocytoplasmic transfer of proteins and RNAs. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Further reading

• Wong WT, Schumacher C, Salcini AE, etal . A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution. . Proc. Natl. Acad. Sci. U.S.A. . 92 . 21 . 9530–4 . 1995 . 7568168 . 10.1073/pnas.92.21.9530 . 40835 . 1995PNAS...92.9530W . free .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Salcini AE, Confalonieri S, Doria M, etal . Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module. . Genes Dev. . 11 . 17 . 2239–49 . 1997 . 9303539 . 10.1101/gad.11.17.2239 . 275390 .
• Doria M, Salcini AE, Colombo E, etal . The eps15 homology (EH) domain-based interaction between eps15 and hrb connects the molecular machinery of endocytosis to that of nucleocytosolic transport. . J. Cell Biol. . 147 . 7 . 1379–84 . 2000 . 10613896 . 10.1083/jcb.147.7.1379 . 2174238 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Scherer SW, Cheung J, MacDonald JR, etal . Human chromosome 7: DNA sequence and biology. . Science . 300 . 5620 . 767–72 . 2003 . 12690205 . 2882961 . 10.1126/science.1083423 . 2003Sci...300..767S .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .

Notes and References

1. Glockner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A . Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes . Genome Res . 8 . 10 . 1060–73 . Dec 1998 . 9799793 . 310788 . 10.1101/gr.8.10.1060.
2. Web site: Entrez Gene: HRBL HIV-1 Rev binding protein-like.