HPSE2 explained

Heparanase-2 is an enzyme that in humans is encoded by the HPSE2 gene.^{[1] [2]}

It may be associated with urofacial syndrome.^[3]

Further reading

• D'Souza SS, Fazleabas AT, Banerjee P, etal . Decidual heparanase activity is increased during pregnancy in the baboon (Papio anubis) and in in vitro decidualization of human stromal cells . Biol. Reprod. . 78 . 2 . 316–23 . 2008 . 17989358 . 10.1095/biolreprod.107.063891 . 32383560 . free .
• Bar-Sela G, Kaplan-Cohen V, Ilan N, etal . Heparanase expression in nasopharyngeal carcinoma inversely correlates with patient survival . Histopathology . 49 . 2 . 188–93 . 2006 . 16879396 . 10.1111/j.1365-2559.2006.02469.x . 46173868 .
• Beckhove P, Helmke BM, Ziouta Y, etal . Heparanase expression at the invasion front of human head and neck cancers and correlation with poor prognosis . Clin. Cancer Res. . 11 . 8 . 2899–906 . 2005 . 15837740 . 10.1158/1078-0432.CCR-04-0664 . 22489633 .
• Ogishima T, Shiina H, Breault JE, etal . Increased heparanase expression is caused by promoter hypomethylation and up-regulation of transcriptional factor early growth response-1 in human prostate cancer . Clin. Cancer Res. . 11 . 3 . 1028–36 . 2005 . 10.1158/1078-0432.1028.11.3 . 15709168 . free .
• Wang Z, Xu H, Jiang L, etal . Positive association of heparanase expression with tumor invasion and lymphatic metastasis in gastric carcinoma . Mod. Pathol. . 18 . 2 . 205–11 . 2005 . 15475937 . 10.1038/modpathol.3800282 . free .
• Deloukas P, Earthrowl ME, Grafham DV, etal . The DNA sequence and comparative analysis of human chromosome 10 . Nature . 429 . 6990 . 375–81 . 2004 . 15164054 . 10.1038/nature02462 . 2004Natur.429..375D . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .

Notes and References

1. McKenzie E, Tyson K, Stamps A, Smith P, Turner P, Barry R, Hircock M, Patel S, Barry E, Stubberfield C, Terrett J, Page M . Cloning and expression profiling of Hpa2, a novel mammalian heparanase family member . Biochem Biophys Res Commun . 276 . 3 . 1170–7 . Oct 2000 . 11027606 . 10.1006/bbrc.2000.3586 .
2. Web site: Entrez Gene: HPSE2 heparanase 2.
3. Daly SB, Urquhart JE, Hilton E, etal . Mutations in HPSE2 Cause Urofacial Syndrome . Am J Hum Genet . 86. 6. 963–969. June 2010 . 20560210 . 10.1016/j.ajhg.2010.05.006 . 3032078.