Hippocalcin-like protein 1 explained

Hippocalcin-like protein 1 is a protein that in humans is encoded by the HPCAL1 gene.^{[1] [2] [3]}

The protein encoded by this gene is a member of the neuron-specific calcium-binding proteins family found in the retina and brain.^[4] It is highly similar to human hippocalcin protein, and nearly identical to rat and mouse hippocalcin like-1 proteins. It may be involved in the calcium-dependent regulation of rhodopsin phosphorylation, and may be of relevance to neuronal signaling in the central nervous system. There are two alternatively spliced transcript variants of this gene, with multiple polyadenylation sites.

Further reading

• Hidaka H, Okazaki K . Neurocalcin family: a novel calcium-binding protein abundant in bovine central nervous system . Neurosci. Res. . 16 . 2 . 73–7 . 1993 . 8387172 . 10.1016/0168-0102(93)90074-Z . 4210072 .
• Andersson B . A "double adaptor" method for improved shotgun library construction . Anal. Biochem. . 236 . 1 . 107–13 . 1996 . 8619474 . 10.1006/abio.1996.0138 . vanc. Wentland MA . Ricafrente JY . 3 . Liu . W . Gibbs . RA .
• Yu W . Large-Scale Concatenation cDNA Sequencing . Genome Res. . 7 . 4 . 353–8 . 1997 . 9110174 . 10.1101/gr.7.4.353. 139146 . vanc. Andersson B . Worley KC . 3 . Muzny . DM . Ding . Y . Liu . W . Ricafrente . JY . Wentland . MA . Lennon . G .
• Spilker C . The neuronal EF-hand calcium-binding protein visinin-like protein-3 is expressed in cerebellar Purkinje cells and shows a calcium-dependent membrane association . Neuroscience . 96 . 1 . 121–9 . 2000 . 10683417 . 10.1016/S0306-4522(99)00536-9 . vanc. Richter K . Smalla KH . 3 . Manahan-Vaughan . D . Gundelfinger . ED . Braunewell . KH . 22063490 .
• Bernstein HG . Regional and cellular distribution of neural visinin-like protein immunoreactivities (VILIP-1 and VILIP-3) in human brain . J. Neurocytol. . 28 . 8 . 655–62 . 2000 . 10851344 . 10.1023/A:1007056731551 . vanc. Baumann B . Danos P . 3 . Diekmann . Silvia . Bogerts . Bernhard . Gundelfinger . Eckart D. . Braunewell . Karl-Heinz . 7944931 .
• Hartley JL, Temple GF, Brasch MA . DNA Cloning Using In Vitro Site-Specific Recombination . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Braunewell K . Abnormal localization of two neuronal calcium sensor proteins, visinin-like proteins (vilips)-1 and -3, in neocortical brain areas of Alzheimer disease patients . Dementia and Geriatric Cognitive Disorders . 12 . 2 . 110–6 . 2001 . 11173883 . 10.1159/000051244 . vanc. Riederer P . Spilker C . 3 . Gundelfinger . E.D. . Bogerts . B. . Bernstein . H.-G. . 21446098 .
• Ivings L . Identification of Ca2+-dependent binding partners for the neuronal calcium sensor protein neurocalcin delta: interaction with actin, clathrin and tubulin . Biochem. J. . 363 . Pt 3 . 599–608 . 2002 . 11964161 . 10.1042/0264-6021:3630599 . 1222513 . vanc. Pennington SR . Jenkins R . 3 . Weiss . Jamie L. . Burgoyne . Robert D. .
• Spilker C, Gundelfinger ED, Braunewell KH . Evidence for different functional properties of the neuronal calcium sensor proteins VILIP-1 and VILIP-3: from subcellular localization to cellular function . Biochim. Biophys. Acta . 1600 . 1–2 . 118–27 . 2002 . 12445467 . 10.1016/s1570-9639(02)00452-1.
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Pribanic S . Expression of visinin-like protein-3 in mouse kidney . Nephron Physiology . 95 . 4 . 76–82 . 2004 . 14694264 . 10.1159/000074844 . vanc. Loffing J . Madjdpour C . 3 . Bacic . Desa . Gisler . Serge . Braunewell . Karl-Heinz . Biber . JÜrg . Murer . Heini . 4883128 .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Wiemann S . From ORFeome to Biology: A Functional Genomics Pipeline . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 10.1101/gr.2576704 . 528930 . vanc. Arlt D . Huber W . 3 . Wellenreuther . R . Schleeger . S . Mehrle . A . Bechtel . S . Sauermann . M . Korf . U .
• Rual JF . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . vanc. Venkatesan K . Hao T . 3 . Hirozane-Kishikawa . Tomoko . Dricot . Amélie . Li . Ning . Berriz . Gabriel F. . Gibbons . Francis D. . Dreze . Matija . 2005Natur.437.1173R . 4427026 .
• Mehrle A . The LIFEdb database in 2006 . Nucleic Acids Res. . 34 . Database issue . D415–8 . 2006 . 16381901 . 10.1093/nar/gkj139 . 1347501 . vanc. Rosenfelder H . Schupp I . 3 . Del Val . C . Arlt . D . Hahne . F . Bechtel . S . Simpson . J . Hofmann . O .
• Jheng FF, Wang L, Lee L, Chang LS . Functional contribution of Ca2+ and Mg2+ to the intermolecular interaction of visinin-like proteins . Protein J. . 25 . 4 . 250–6 . 2007 . 16703469 . 10.1007/s10930-006-9008-5 . 29486237 .
• Lim J . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . vanc. Hao T . Shaw C . 3 . Patel . Akash J. . Szabó . Gábor . Rual . Jean-François . Fisk . C. Joseph . Li . Ning . Smolyar . Alex . 13709685 . free .

Notes and References

1. Kobayashi M, Takamatsu K, Fujishiro M, Saitoh S, Noguchi T . Molecular cloning of a novel calcium-binding protein structurally related to hippocalcin from human brain and chromosomal mapping of its gene . Biochim Biophys Acta . 1222 . 3 . 515–8 . Aug 1994 . 8038222 . 10.1016/0167-4889(94)90062-0 .
2. Oikawa K, Kimura S, Aoki N, Atsuta Y, Takiyama Y, Nagato T, Yanai M, Kobayashi H, Sato K, Sasajima T, Tateno M . Neuronal calcium sensor protein visinin-like protein-3 interacts with microsomal cytochrome b5 in a Ca2+-dependent manner . J Biol Chem . 279 . 15 . 15142–52 . Apr 2004 . 14739275 . 10.1074/jbc.M312766200 . free .
3. Web site: Entrez Gene: HPCAL1 hippocalcin-like 1.
4. Burgoyne RD. Neuronal Calcium Sensor Proteins: Generating Diversity in Neuronal Ca2+ Signalling. Nat. Rev. Neurosci. . 8 . 3 . 182–193 . 2007 . 17311005 . 1887812 . 10.1038/nrn2093 .