HOXC8 explained

Homeobox protein Hox-C8 is a protein that in humans is encoded by the HOXC8 gene.^{[1] [2] [3]}

Function

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the regulation of cartilage differentiation. It could also be involved in chondrodysplasias or other cartilage disorders. HOXC8 was found to have activity in promoting nerve growth and its expression is dysregulated in patients with neurofibromatosis type 1.^[4]

See also

• Homeobox

Interactions

HOXC8 has been shown to interact with Mothers against decapentaplegic homolog 6^[5] and Mothers against decapentaplegic homolog 1.^[6]

Further reading

• Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E . The human HOX gene family . Nucleic Acids Res. . 17 . 24 . 10385–402 . 1989 . 2574852 . 335308 . 10.1093/nar/17.24.10385 .
• Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A . Organization of human class I homeobox genes . Genome . 31 . 2 . 745–56 . 1989 . 2576652 . 10.1139/g89-133 .
• Rabin M, Ferguson-Smith A, Hart CP, Ruddle FH . Cognate homeo-box loci mapped on homologous human and mouse chromosomes . Proc. Natl. Acad. Sci. U.S.A. . 83 . 23 . 9104–8 . 1986 . 2878432 . 387083 . 10.1073/pnas.83.23.9104 . 1986PNAS...83.9104R . free .
• Simeone A, Mavilio F, Acampora D, Giampaolo A, Faiella A, Zappavigna V, D'Esposito M, Pannese M, Russo G, Boncinelli E . Two human homeobox genes, c1 and c8: structure analysis and expression in embryonic development . Proc. Natl. Acad. Sci. U.S.A. . 84 . 14 . 4914–8 . 1987 . 2885844 . 305217 . 10.1073/pnas.84.14.4914 . 1987PNAS...84.4914S . free .
• Cannizzaro LA, Croce CM, Griffin CA, Simeone A, Boncinelli E, Huebner K . Human homeo box-containing genes located at chromosome regions 2q31----2q37 and 12q12----12q13 . Am. J. Hum. Genet. . 41 . 1 . 1–15 . 1987 . 2886047 . 1684175 .
• Lawrence HJ, Stage KM, Mathews CH, Detmer K, Scibienski R, MacKenzie M, Migliaccio E, Boncinelli E, Largman C . Expression of HOX C homeobox genes in lymphoid cells . Cell Growth Differ. . 4 . 8 . 665–9 . 1993 . 8104467 .
• Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B . Fine mapping of human HOX gene clusters . Cytogenet. Cell Genet. . 73 . 1–2 . 114–5 . 1996 . 8646877 . 10.1159/000134320 .
• Flagiello D, Gibaud A, Dutrillaux B, Poupon MF, Malfoy B . Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines . FEBS Lett. . 415 . 3 . 263–7 . 1997 . 9357979 . 10.1016/S0014-5793(97)01118-6 . 1997FEBSL.415..263F . 26075369 .
• Shi X, Yang X, Chen D, Chang Z, Cao X . Smad1 interacts with homeobox DNA-binding proteins in bone morphogenetic protein signaling . J. Biol. Chem. . 274 . 19 . 13711–7 . 1999 . 10224145 . 10.1074/jbc.274.19.13711 . free .
• Prévôt D, Voeltzel T, Birot AM, Morel AP, Rostan MC, Magaud JP, Corbo L . The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation . J. Biol. Chem. . 275 . 1 . 147–53 . 2000 . 10617598 . 10.1074/jbc.275.1.147 . free .
• Bai S, Shi X, Yang X, Cao X . Smad6 as a transcriptional corepressor . J. Biol. Chem. . 275 . 12 . 8267–70 . 2000 . 10722652 . 10.1074/jbc.275.12.8267 . free .
• Wan M, Shi X, Feng X, Cao X . Transcriptional mechanisms of bone morphogenetic protein-induced osteoprotegrin gene expression . J. Biol. Chem. . 276 . 13 . 10119–25 . 2001 . 11139569 . 10.1074/jbc.M006918200 . free .
• Schaefer LK, Wang S, Schaefer TS . Functional interaction of Jun and homeodomain proteins . J. Biol. Chem. . 276 . 46 . 43074–82 . 2001 . 11551904 . 10.1074/jbc.M102552200 . free .
• Waltregny D, Alami Y, Clausse N, de Leval J, Castronovo V . Overexpression of the homeobox gene HOXC8 in human prostate cancer correlates with loss of tumor differentiation . Prostate . 50 . 3 . 162–9 . 2002 . 11813208 . 10.1002/pros.10045 . 32810610 .
• Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N . Complete mutation analysis panel of the 39 human HOX genes . Teratology . 65 . 2 . 50–62 . 2002 . 11857506 . 10.1002/tera.10009 .
• Bayarsaihan D, Enkhmandakh B, Makeyev A, Greally JM, Leckman JF, Ruddle FH . Homez, a homeobox leucine zipper gene specific to the vertebrate lineage . Proc. Natl. Acad. Sci. U.S.A. . 100 . 18 . 10358–63 . 2003 . 12925734 . 193566 . 10.1073/pnas.1834010100 . 2003PNAS..10010358B . free .
• Luo L, Yang X, Takihara Y, Knoetgen H, Kessel M . The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions . Nature . 427 . 6976 . 749–53 . 2004 . 14973489 . 10.1038/nature02305 . 2004Natur.427..749L . 11858/00-001M-0000-0012-EE33-0 . 8020382 . free .

Notes and References

1. McAlpine PJ, Shows TB . Nomenclature for human homeobox genes . Genomics . 7 . 3 . 460 . August 1990 . 1973146 . 10.1016/0888-7543(90)90186-X .
2. Scott MP . Vertebrate homeobox gene nomenclature . Cell . 71 . 4 . 551–3 . December 1992 . 1358459 . 10.1016/0092-8674(92)90588-4 . 13370372 .
3. Web site: Entrez Gene: HOXC8 homeobox C8.
4. Liu Y, Kang D, Li C, Xu G, Tan Y, Wang J . Microarray‑based identification of nerve growth‑promoting genes in neurofibromatosis type I . Mol Med Rep . 9 . 1 . 192–6 . Jan 2014 . 24213587 . 10.3892/mmr.2013.1785 . free .
5. Bai S, Shi X, Yang X, Cao X . Smad6 as a transcriptional corepressor . J. Biol. Chem. . 275 . 12 . 8267–70 . March 2000 . 10722652 . 10.1074/jbc.275.12.8267 . free .
6. Shi X, Yang X, Chen D, Chang Z, Cao X . Smad1 interacts with homeobox DNA-binding proteins in bone morphogenetic protein signaling . J. Biol. Chem. . 274 . 19 . 13711–7 . May 1999 . 10224145 . 10.1074/jbc.274.19.13711 . free .