HOXC13 explained

Homeobox protein Hox-C13 is a protein that in humans is encoded by the HOXC13 gene.^{[1] [2] [3]}

Function

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the development of hair, nail, and filiform papilla.

See also

• Homeobox

Further reading

• Godwin AR, Capecchi MR . Hair defects in Hoxc13 mutant mice . The Journal of Investigative Dermatology. Symposium Proceedings . 4 . 3 . 244–7 . Dec 1999 . 10674376 . 10.1038/sj.jidsp.5640221 . free .
• Panagopoulos I, Isaksson M, Billström R, Strömbeck B, Mitelman F, Johansson B . Fusion of the NUP98 gene and the homeobox gene HOXC13 in acute myeloid leukemia with t(11;12)(p15;q13) . Genes, Chromosomes & Cancer . 36 . 1 . 107–12 . Jan 2003 . 12461755 . 10.1002/gcc.10139 . 43580734 .
• Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E . The human HOX gene family . Nucleic Acids Research . 17 . 24 . 10385–402 . Dec 1989 . 2574852 . 335308 . 10.1093/nar/17.24.10385 .
• Rabin M, Ferguson-Smith A, Hart CP, Ruddle FH . Cognate homeo-box loci mapped on homologous human and mouse chromosomes . Proceedings of the National Academy of Sciences of the United States of America . 83 . 23 . 9104–8 . Dec 1986 . 2878432 . 387083 . 10.1073/pnas.83.23.9104 . 1986PNAS...83.9104R . free .
• Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B . Fine mapping of human HOX gene clusters . Cytogenetics and Cell Genetics . 73 . 1–2 . 114–5 . 1996 . 8646877 . 10.1159/000134320 .
• Flagiello D, Gibaud A, Dutrillaux B, Poupon MF, Malfoy B . Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines . FEBS Letters . 415 . 3 . 263–7 . Oct 1997 . 9357979 . 10.1016/S0014-5793(97)01118-6 . 1997FEBSL.415..263F . 26075369 .
• de Stanchina E, Gabellini D, Norio P, Giacca M, Peverali FA, Riva S, Falaschi A, Biamonti G . Selection of homeotic proteins for binding to a human DNA replication origin . Journal of Molecular Biology . 299 . 3 . 667–80 . Jun 2000 . 10835276 . 10.1006/jmbi.2000.3782 .
• Kulessa H, Turk G, Hogan BL . Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle . The EMBO Journal . 19 . 24 . 6664–74 . Dec 2000 . 11118201 . 305899 . 10.1093/emboj/19.24.6664 .
• Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N . Complete mutation analysis panel of the 39 human HOX genes . Teratology . 65 . 2 . 50–62 . Feb 2002 . 11857506 . 10.1002/tera.10009 .
• Pruett ND, Tkatchenko TV, Jave-Suarez L, Jacobs DF, Potter CS, Tkatchenko AV, Schweizer J, Awgulewitsch A . Krtap16, characterization of a new hair keratin-associated protein (KAP) gene complex on mouse chromosome 16 and evidence for regulation by Hoxc13 . The Journal of Biological Chemistry . 279 . 49 . 51524–33 . Dec 2004 . 15385554 . 10.1074/jbc.M404331200 . free .

Notes and References

1. McAlpine PJ, Shows TB . Nomenclature for human homeobox genes . Genomics . 7 . 3 . 460 . Jul 1990 . 1973146 . 10.1016/0888-7543(90)90186-X .
2. Scott MP . Vertebrate homeobox gene nomenclature . Cell . 71 . 4 . 551–3 . Nov 1992 . 1358459 . 10.1016/0092-8674(92)90588-4 . 13370372 .
3. Web site: Entrez Gene: HOXC13 homeobox C13.