HOXC12 explained

Homeobox C12 is a protein that in humans is encoded by the HOXC12 gene.^[1]

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12.^[2]

Further reading

• Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N . Complete mutation analysis panel of the 39 human HOX genes . Teratology . 65 . 2 . 50–62 . February 2002 . 11857506 . 10.1002/tera.10009 .
• Scott MP . Vertebrate homeobox gene nomenclature . Cell . 71 . 4 . 551–3 . November 1992 . 1358459 . 10.1016/0092-8674(92)90588-4 . 13370372 .
• McAlpine PJ, Shows TB . Nomenclature for human homeobox genes . Genomics . 7 . 3 . 460 . July 1990 . 1973146 . 10.1016/0888-7543(90)90186-X .
• Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E . The human HOX gene family . Nucleic Acids Research . 17 . 24 . 10385–402 . December 1989 . 2574852 . 335308 . 10.1093/nar/17.24.10385 .
• Flagiello D, Gibaud A, Dutrillaux B, Poupon MF, Malfoy B . Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines . FEBS Letters . 415 . 3 . 263–7 . October 1997 . 9357979 . 10.1016/S0014-5793(97)01118-6 . 1997FEBSL.415..263F . 26075369 .

Notes and References

1. Web site: Entrez Gene: Homeobox C12. 2011-11-11 .
2. Web site: Entrez Gene: Homeobox C12. 2011-11-11 .