HOXC11 explained

Homeobox protein Hox-C11 is a protein that in humans is encoded by the HOXC11 gene.^{[1] [2] [3]}

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms.

Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene binds to a promoter element of the lactase-phlorizin hydrolase. It also may play a role in early intestinal development. An alternatively spliced variant encoding a shorter isoform has been described but its full-length nature has not been determined.

Further reading

• Acampora D . The human HOX gene family . Nucleic Acids Res. . 17 . 24 . 10385–10402 . 1990 . 2574852 . 10.1093/nar/17.24.10385 . 335308 . vanc. D'Esposito M . Faiella A . 3 . Pannese . Maria . Migliaccio . Enrica . Morelli . Franco . Stornaiuolo . Anna . Nigro . Vincenzo . Simeone . Antonio .
• Rabin M, Ferguson-Smith A, Hart CP, Ruddle FH . Cognate homeo-box loci mapped on homologous human and mouse chromosomes . Proc. Natl. Acad. Sci. U.S.A. . 83 . 23 . 9104–9108 . 1987 . 2878432 . 10.1073/pnas.83.23.9104 . 387083 . 1986PNAS...83.9104R . free .
• Apiou F . Fine mapping of human HOX gene clusters . Cytogenet. Cell Genet. . 73 . 1–2 . 114–115 . 1996 . 8646877 . 10.1159/000134320 . vanc. Flagiello D . Cillo C . 3 . Malfoy . B. . Poupon . M.-F. . Dutrillaux . B. .
• Flagiello D . Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines . FEBS Lett. . 415 . 3 . 263–267 . 1997 . 9357979 . 10.1016/S0014-5793(97)01118-6 . vanc. Gibaud A . Dutrillaux B . 3 . Poupon . MF . Malfoy . B . 1997FEBSL.415..263F . 26075369 .
• Mitchelmore C, Troelsen JT, Sjöström H, Norén O . The HOXC11 homeodomain protein interacts with the lactase-phlorizin hydrolase promoter and stimulates HNF1alpha-dependent transcription . J. Biol. Chem. . 273 . 21 . 13297–13306 . 1998 . 9582375 . 10.1074/jbc.273.21.13297 . free .
• Kosaki K . Complete mutation analysis panel of the 39 human HOX genes . Teratology . 65 . 2 . 50–62 . 2002 . 11857506 . 10.1002/tera.10009 . vanc. Kosaki R . Suzuki T . 3 . Yoshihashi . Hiroshi . Takahashi . Takao . Sasaki . Katsumi . Tomita . Masaru . McGinnis . William . Matsuo . Nobutake .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–2127 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Zhang X . HOXC6 and HOXC11 increase transcription of S100beta gene in BrdU-induced in vitro differentiation of GOTO neuroblastoma cells into Schwannian cells . J. Cell. Mol. Med. . 11 . 2 . 299–306 . 2007 . 17488478 . 10.1111/j.1582-4934.2007.00020.x . vanc. Hamada J . Nishimoto A . 3 . Takahashi . Yoko . Murai . Taichi . Tada . Mitsuhiro . Moriuchi . Tetsuya . 3822828 .

Notes and References

1. McAlpine PJ, Shows TB . Nomenclature for human homeobox genes . Genomics . 7 . 3 . 460 . Aug 1990 . 1973146 . 10.1016/0888-7543(90)90186-X .
2. Scott MP . Vertebrate homeobox gene nomenclature . Cell . 71 . 4 . 551–553 . Dec 1992 . 1358459 . 10.1016/0092-8674(92)90588-4 . 13370372 .
3. Web site: Entrez Gene: HOXC11 homeobox C11.