HOXB3 explained

Homeobox protein Hox-B3 is a protein that in humans is encoded by the HOXB3 gene.^{[1] [2] [3]}

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML).

See also

• Homeobox

Further reading

• Giampaolo A . Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system . Differentiation . 40 . 3 . 191–7 . 1989 . 2570724 . 10.1111/j.1432-0436.1989.tb00598.x . vanc. Acampora D . Zappavigna V . 3 . Pannese . Maria . d'Esposito . Maurizio . Care . Alessandra . Feiella . Antonio . Stornaiuolo . Anna . Russo . Giovanni .
• Acampora D . The human HOX gene family . Nucleic Acids Res. . 17 . 24 . 10385–402 . 1990 . 2574852 . 10.1093/nar/17.24.10385 . 335308 . vanc. D'Esposito M . Faiella A . 3 . Pannese . Maria . Migliaccio . Enrica . Morelli . Franco . Stornaiuolo . Anna . Nigro . Vincenzo . Simeone . Antonio .
• Boncinelli E . Organization of human class I homeobox genes . Genome . 31 . 2 . 745–56 . 1990 . 2576652 . 10.1139/g89-133. vanc. Acampora D . Pannese M . 3 . d'Esposito . M . Somma . R . Gaudino . G . Stornaiuolo . A . Cafiero . M . Faiella . A .
• Guazzi S . The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins . EMBO J. . 13 . 14 . 3339–47 . 1994 . 7913891 . 10.1002/j.1460-2075.1994.tb06636.x. 395231 . vanc. Lonigro R . Pintonello L . 3 . Boncinelli . E . Di Lauro . R . Mavilio . F .
• Apiou F . Fine mapping of human HOX gene clusters . Cytogenet. Cell Genet. . 73 . 1–2 . 114–5 . 1996 . 8646877 . 10.1159/000134320 . vanc. Flagiello D . Cillo C . 3 . Malfoy . B. . Poupon . M.-F. . Dutrillaux . B. .
• Bingle CD, Gowan S . Oct-1 interacts with conserved motifs in the human thyroid transcription factor 1 gene minimal promoter . Biochem. J. . 319 (Pt 3) . Pt 3. 669–74 . 1996 . 8920965 . 10.1042/bj3190669. 1217841 .
• Sauvageau G . Overexpression of HOXB3 in hematopoietic cells causes defective lymphoid development and progressive myeloproliferation . Immunity . 6 . 1 . 13–22 . 1997 . 9052833 . 10.1016/S1074-7613(00)80238-1 . vanc. Thorsteinsdottir U . Hough MR . 3 . Hugo . Patrice . Lawrence . H.Jeffrey . Largman . Corey . Humphries . R.Keith . free .
• Guazzi S, Pintonello ML, Viganò A, Boncinelli E . Regulatory interactions between the human HOXB1, HOXB2, and HOXB3 proteins and the upstream sequence of the Otx2 gene in embryonal carcinoma cells . J. Biol. Chem. . 273 . 18 . 11092–9 . 1998 . 9556594 . 10.1074/jbc.273.18.11092 . free .
• Viganò MA, Di Rocco G, Zappavigna V, Mavilio F . Definition of the Transcriptional Activation Domains of Three Human HOX Proteins Depends on the DNA-Binding Context . Mol. Cell. Biol. . 18 . 11 . 6201–12 . 1998 . 9774637 . 10.1128/MCB.18.11.6201. 109207 .
• Kosaki K . Complete mutation analysis panel of the 39 human HOX genes . Teratology . 65 . 2 . 50–62 . 2002 . 11857506 . 10.1002/tera.10009 . vanc. Kosaki R . Suzuki T . 3 . Yoshihashi . Hiroshi . Takahashi . Takao . Sasaki . Katsumi . Tomita . Masaru . McGinnis . William . Matsuo . Nobutake .
• Nakamura N, Yoshimi T, Miura T . Increased gene expression of lung marker proteins in the homeobox B3-overexpressed fetal lung cell line M3E3/C3 . Cell Growth Differ. . 13 . 4 . 195–203 . 2002 . 11971819 .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Pineault N, Abramovich C, Ohta H, Humphries RK . Differential and Common Leukemogenic Potentials of Multiple NUP98-Hox Fusion Proteins Alone or with Meis1 . Mol. Cell. Biol. . 24 . 5 . 1907–17 . 2004 . 14966272 . 10.1128/MCB.24.5.1907-1917.2004 . 350554 .
• Roche J . Hox expression in AML identifies a distinct subset of patients with intermediate cytogenetics . Leukemia . 18 . 6 . 1059–63 . 2004 . 15085154 . 10.1038/sj.leu.2403366 . vanc. Zeng C . Barón A . 3 . Gadgil . S . Gemmill . R M . Tigaud . I . Thomas . X . Drabkin . H A . 9417756 .
• Brandenberger R . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation . Nat. Biotechnol. . 22 . 6 . 707–16 . 2005 . 15146197 . 10.1038/nbt971 . vanc. Wei H . Zhang S . 3 . Lei . Shirley . Murage . Jaji . Fisk . Gregory J . Li . Yan . Xu . Chunhui . Fang . Rixun . 27764390 .
• Speleman F . A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias . Leukemia . 19 . 3 . 358–66 . 2005 . 15674412 . 10.1038/sj.leu.2403657 . vanc. Cauwelier B . Dastugue N . 3 . Cools . J . Verhasselt . B . Poppe . B . Van Roy . N . Vandesompele . J . Graux . C . free . 1854/LU-349753 . free .
• Kimura K . Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . vanc. Wakamatsu A . Suzuki Y . 3 . Ota . T . Nishikawa . T . Yamashita . R . Yamamoto . J . Sekine . M . Tsuritani . K .

Notes and References

1. McAlpine PJ, Shows TB . Nomenclature for human homeobox genes . Genomics . 7 . 3 . 460 . Aug 1990 . 1973146 . 10.1016/0888-7543(90)90186-X .
2. Scott MP . Vertebrate homeobox gene nomenclature . Cell . 71 . 4 . 551–3 . Dec 1992 . 1358459 . 10.1016/0092-8674(92)90588-4 . 13370372 .
3. Web site: Entrez Gene: HOXB3 homeobox B3.