HOXA7 explained

Homeobox protein Hox-A7 is a protein that in humans is encoded by the HOXA7 gene.^{[1] [2] [3]}

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila.^[4]

See also

• Homeobox

References

Further reading

• Balling R, Mutter G, Gruss P, Kessel M . Craniofacial abnormalities induced by ectopic expression of the homeobox gene Hox-1.1 in transgenic mice . Cell . 58 . 2 . 337–347 . July 1989 . 2568891 . 10.1016/0092-8674(89)90848-9 . free . 43658121 . 11858/00-001M-0000-002C-3E33-1 .
• Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E . The human HOX gene family . Nucleic Acids Research . 17 . 24 . 10385–10402 . December 1989 . 2574852 . 335308 . 10.1093/nar/17.24.10385 .
• Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A . Organization of human class I homeobox genes . Genome . 31 . 2 . 745–756 . 1990 . 2576652 . 10.1139/g89-133 .
• Verlinsky Y, Morozov G, Gindilis V, Strom CM, Freidin M, Rechitsky S, Verlinsky O, Ivakhnenko V, Zdanovsky V, Kuliev A . Homeobox gene expression in human oocytes and preembryos . Molecular Reproduction and Development . 41 . 2 . 127–132 . June 1995 . 7654365 . 10.1002/mrd.1080410202 . 43123886 .
• Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B . Fine mapping of human HOX gene clusters . Cytogenetics and Cell Genetics . 73 . 1-2 . 114–115 . 1996 . 8646877 . 10.1159/000134320 .
• Knoepfler PS, Calvo KR, Chen H, Antonarakis SE, Kamps MP . Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1 . Proceedings of the National Academy of Sciences of the United States of America . 94 . 26 . 14553–14558 . December 1997 . 9405651 . 25052 . 10.1073/pnas.94.26.14553 . free . 1997PNAS...9414553K .
• Min W, Woo HJ, Lee CS, Lee KK, Yoon WK, Park HW, Kim MH . 307-bp fragment in HOXA7 upstream sequence is sufficient for anterior boundary formation . DNA and Cell Biology . 17 . 3 . 293–299 . March 1998 . 9539109 . 10.1089/dna.1998.17.293 .
• McIlhatton MA, Bremner P, McMullin MF, Maxwell AP, Winter PC, Lappin TR . Sequence characterisation and expression of homeobox HOX A7 in the multi-potential erythroleukaemic cell line TF-1 . Biochimica et Biophysica Acta . 1442 . 2-3 . 329–333 . November 1998 . 9804983 . 10.1016/s0167-4781(98)00170-5 .
• Toward a complete human genome sequence . Genome Research . 8 . 11 . 1097–1108 . November 1998 . 9847074 . 10.1101/gr.8.11.1097 . free .
• Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ . Shotgun sequencing of the human transcriptome with ORF expressed sequence tags . Proceedings of the National Academy of Sciences of the United States of America . 97 . 7 . 3491–3496 . March 2000 . 10737800 . 16267 . 10.1073/pnas.97.7.3491 . free . 2000PNAS...97.3491D .
• Kim MH, Jin H, Seol EY, Yoo M, Park HW . Sequence analysis and tissue specific expression of human HOXA7 . Molecular Biotechnology . 14 . 1 . 19–24 . January 2000 . 10911612 . 10.1385/MB:14:1:19 . 25333474 .
• La Celle PT, Polakowska RR . Human homeobox HOXA7 regulates keratinocyte transglutaminase type 1 and inhibits differentiation . The Journal of Biological Chemistry . 276 . 35 . 32844–32853 . August 2001 . 11435435 . 10.1074/jbc.M104598200 . free .
• Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N . Complete mutation analysis panel of the 39 human HOX genes . Teratology . 65 . 2 . 50–62 . February 2002 . 11857506 . 10.1002/tera.10009 .
• Bertrand FE, Spengeman JD, Shah N, LeBien TW . B-cell development in the presence of the MLL/AF4 oncoprotein proceeds in the absence of HOX A7 and HOX A9 expression . Leukemia . 17 . 12 . 2454–2459 . December 2003 . 14562113 . 10.1038/sj.leu.2403178 . free .

Notes and References

1. McAlpine PJ, Shows TB . Nomenclature for human homeobox genes . Genomics . 7 . 3 . 460 . July 1990 . 1973146 . 10.1016/0888-7543(90)90186-X .
2. Scott MP . Vertebrate homeobox gene nomenclature . Cell . 71 . 4 . 551–553 . November 1992 . 1358459 . 10.1016/0092-8674(92)90588-4 . 13370372 .
3. Web site: Entrez Gene: HOXA7 homeobox A7.
4. Web site: Entrez Gene: HOXA7 homeobox A7.