Homeobox A10 Explained

Homeobox protein Hox-A10 is a protein that in humans is encoded by the HOXA10 gene.^{[1] [2] [3]}

Function

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants encoding different isoforms have been described.Downregulation of HOXA10 is observed in the human and baboon decidua after implantation and this downregulation promotes trophoblast invasion by activating STAT3.^[4]

Interactions

Homeobox A10 has been shown to interact with PTPN6.^[5]

See also

• Homeobox

Further reading

• Eun Kwon H, Taylor HS . The role of HOX genes in human implantation . Annals of the New York Academy of Sciences . 1034 . 1 . 1–18 . December 2004 . 15731295 . 10.1196/annals.1335.001 . 41501204 . 2004NYASA1034....1E .
• Lowney P, Corral J, Detmer K, LeBeau MM, Deaven L, Lawrence HJ, Largman C . A human Hox 1 homeobox gene exhibits myeloid-specific expression of alternative transcripts in human hematopoietic cells . Nucleic Acids Research . 19 . 12 . 3443–3449 . June 1991 . 1676505 . 328346 . 10.1093/nar/19.12.3443 .
• Shen WF, Largman C, Lowney P, Corral JC, Detmer K, Hauser CA, Simonitch TA, Hack FM, Lawrence HJ . Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines . Proceedings of the National Academy of Sciences of the United States of America . 86 . 21 . 8536–8540 . November 1989 . 2573064 . 298317 . 10.1073/pnas.86.21.8536 . free . 1989PNAS...86.8536S .
• Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E . The human HOX gene family . Nucleic Acids Research . 17 . 24 . 10385–10402 . December 1989 . 2574852 . 335308 . 10.1093/nar/17.24.10385 .
• Sauvageau G, Lansdorp PM, Eaves CJ, Hogge DE, Dragowska WH, Reid DS, Largman C, Lawrence HJ, Humphries RK . Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells . Proceedings of the National Academy of Sciences of the United States of America . 91 . 25 . 12223–12227 . December 1994 . 7527557 . 45409 . 10.1073/pnas.91.25.12223 . free . 1994PNAS...9112223S .
• Lawrence HJ, Sauvageau G, Ahmadi N, Lopez AR, LeBeau MM, Link M, Humphries K, Largman C . Stage- and lineage-specific expression of the HOXA10 homeobox gene in normal and leukemic hematopoietic cells . Experimental Hematology . 23 . 11 . 1160–1166 . October 1995 . 7556525 .
• Satokata I, Benson G, Maas R . Sexually dimorphic sterility phenotypes in Hoxa10-deficient mice . Nature . 374 . 6521 . 460–463 . March 1995 . 7700356 . 10.1038/374460a0 . 4337017 . 1995Natur.374..460S .
• Castronovo V, Kusaka M, Chariot A, Gielen J, Sobel M . Homeobox genes: potential candidates for the transcriptional control of the transformed and invasive phenotype . Biochemical Pharmacology . 47 . 1 . 137–143 . January 1994 . 7906121 . 10.1016/0006-2952(94)90447-2 .
• Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B . Fine mapping of human HOX gene clusters . Cytogenetics and Cell Genetics . 73 . 1–2 . 114–115 . 1996 . 8646877 . 10.1159/000134320 .
• Thorsteinsdottir U, Sauvageau G, Hough MR, Dragowska W, Lansdorp PM, Lawrence HJ, Largman C, Humphries RK . Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia . Molecular and Cellular Biology . 17 . 1 . 495–505 . January 1997 . 8972230 . 231774 . 10.1128/mcb.17.1.495 .
• Shen WF, Montgomery JC, Rozenfeld S, Moskow JJ, Lawrence HJ, Buchberg AM, Largman C . AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins . Molecular and Cellular Biology . 17 . 11 . 6448–6458 . November 1997 . 9343407 . 232497 . 10.1128/MCB.17.11.6448 .
• Taylor HS, Vanden Heuvel GB, Igarashi P . A conserved Hox axis in the mouse and human female reproductive system: late establishment and persistent adult expression of the Hoxa cluster genes . Biology of Reproduction . 57 . 6 . 1338–1345 . December 1997 . 9408238 . 10.1095/biolreprod57.6.1338 . free .
• Taylor HS, Arici A, Olive D, Igarashi P . HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium . The Journal of Clinical Investigation . 101 . 7 . 1379–1384 . April 1998 . 9525980 . 508715 . 10.1172/JCI1057 .
• Kawagoe H, Humphries RK, Blair A, Sutherland HJ, Hogge DE . Expression of HOX genes, HOX cofactors, and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cells . Leukemia . 13 . 5 . 687–698 . May 1999 . 10374871 . 10.1038/sj/leu/2401410 . free .
• Eklund EA, Jalava A, Kakar R . Tyrosine phosphorylation of HoxA10 decreases DNA binding and transcriptional repression during interferon gamma -induced differentiation of myeloid leukemia cell lines . The Journal of Biological Chemistry . 275 . 26 . 20117–20126 . June 2000 . 10766757 . 10.1074/jbc.M907915199 . free .
• Buske C, Feuring-Buske M, Antonchuk J, Rosten P, Hogge DE, Eaves CJ, Humphries RK . Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo . Blood . 97 . 8 . 2286–2292 . April 2001 . 11290589 . 10.1182/blood.V97.8.2286 . free .
• Cermik D, Karaca M, Taylor HS . HOXA10 expression is repressed by progesterone in the myometrium: differential tissue-specific regulation of HOX gene expression in the reproductive tract . The Journal of Clinical Endocrinology and Metabolism . 86 . 7 . 3387–3392 . July 2001 . 11443215 . 10.1210/jcem.86.7.7675 . 23775476 . free .
• Shen WF, Krishnan K, Lawrence HJ, Largman C . The HOX homeodomain proteins block CBP histone acetyltransferase activity . Molecular and Cellular Biology . 21 . 21 . 7509–7522 . November 2001 . 11585930 . 99922 . 10.1128/MCB.21.21.7509-7522.2001 .
• Godbole G, Modi D . Regulation of decidualization, interleukin-11 and interleukin-15 by homeobox A 10 in endometrial stromal cells . Journal of Reproductive Immunology . 85 . 2 . 130–139 . June 2010 . 20478621 . 10.1016/j.jri.2010.03.003 .
• Godbole GB, Modi DN, Puri CP . Regulation of homeobox A10 expression in the primate endometrium by progesterone and embryonic stimuli . Reproduction . 134 . 3 . 513–523 . September 2007 . 17709569 . 10.1530/REP-07-0234 . free .

Notes and References

1. McAlpine PJ, Shows TB . Nomenclature for human homeobox genes . Genomics . 7 . 3 . 460 . July 1990 . 1973146 . 10.1016/0888-7543(90)90186-X .
2. Scott MP . Vertebrate homeobox gene nomenclature . Cell . 71 . 4 . 551–553 . November 1992 . 1358459 . 10.1016/0092-8674(92)90588-4 . 13370372 .
3. Web site: Entrez Gene: HOXA10 homeobox A10.
4. Godbole G, Suman P, Malik A, Galvankar M, Joshi N, Fazleabas A, Gupta SK, Modi D . Decrease in Expression of HOXA10 in the Decidua After Embryo Implantation Promotes Trophoblast Invasion . Endocrinology . 158 . 8 . 2618–2633 . August 2017 . 28520923 . 6283436 . 10.1210/en.2017-00032 .
5. Eklund EA, Goldenberg I, Lu Y, Andrejic J, Kakar R . SHP1 protein-tyrosine phosphatase regulates HoxA10 DNA binding and transcriptional repression activity in undifferentiated myeloid cells . The Journal of Biological Chemistry . 277 . 39 . 36878–36888 . September 2002 . 12145285 . 10.1074/jbc.M203917200 . free .