HOOK3 explained

Protein Hook homolog 3 is a protein that in humans is encoded by the HOOK3 gene.^{[1] [2]}

Function

Hook proteins are cytosolic coiled coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.

Further reading

• Walenta JH, Didier AJ, Liu X, Krämer H . The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins. . J. Cell Biol. . 152 . 5 . 923–34 . 2001 . 11238449 . 10.1083/jcb.152.5.923 . 2198811 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Shotland Y, Krämer H, Groisman EA . The Salmonella SpiC protein targets the mammalian Hook3 protein function to alter cellular trafficking. . Mol. Microbiol. . 49 . 6 . 1565–76 . 2003 . 12950921 . 10.1046/j.1365-2958.2003.03668.x . 30972454 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Kaiser F, Kaufmann SH, Zerrahn J . IIGP, a member of the IFN inducible and microbial defense mediating 47 kDa GTPase family, interacts with the microtubule binding protein hook3. . J. Cell Sci. . 117 . Pt 9 . 1747–56 . 2004 . 15075236 . 10.1242/jcs.01039 . 294834 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Simpson F, Martin S, Evans TM, etal . A novel hook-related protein family and the characterization of hook-related protein 1. . Traffic . 6 . 6 . 442–58 . 2005 . 15882442 . 10.1111/j.1600-0854.2005.00289.x . 25389776 . free .
• Beausoleil SA, Villén J, Gerber SA, etal . A probability-based approach for high-throughput protein phosphorylation analysis and site localization. . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .
• Sano H, Ishino M, Krämer H, etal . The microtubule-binding protein Hook3 interacts with a cytoplasmic domain of scavenger receptor A. . J. Biol. Chem. . 282 . 11 . 7973–81 . 2007 . 17237231 . 10.1074/jbc.M611537200 . free .
• Ciampi R, Giordano TJ, Wikenheiser-Brokamp K, etal . HOOK3-RET: a novel type of RET/PTC rearrangement in papillary thyroid carcinoma. . Endocr. Relat. Cancer . 14 . 2 . 445–52 . 2007 . 17639057 . 10.1677/ERC-07-0039 . free .

Notes and References

1. Kramer H, Phistry M . Genetic analysis of hook, a gene required for endocytic trafficking in drosophila . Genetics . 151 . 2 . 675–84 . Mar 1999 . 10.1093/genetics/151.2.675 . 9927460 . 1460498 .
2. Web site: Entrez Gene: HOOK3 hook homolog 3 (Drosophila).