HOOK2 explained

Protein Hook homolog 2 (HK2) is a protein^[1] that in humans is encoded by the HOOK2 gene.^{[2] [3]}

Function

Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.^[3]

Further reading

• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Xu L, Sowa ME, Chen J, etal . An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex. . Mol. Biol. Cell . 19 . 12 . 5059–71 . 2008 . 18799622 . 10.1091/mbc.E08-05-0473 . 2592673.
• Moynihan KL, Pooley R, Miller PM, etal . Murine CENP-F regulates centrosomal microtubule nucleation and interacts with Hook2 at the centrosome. . Mol. Biol. Cell . 20 . 22 . 4790–803 . 2009 . 19793914 . 10.1091/mbc.E09-07-0560 . 2777108.
• Szebenyi G, Wigley WC, Hall B, etal . Hook2 contributes to aggresome formation. . BMC Cell Biol. . 8 . 19 . 2007 . 17540036 . 10.1186/1471-2121-8-19 . 1896156 . free .
• Szebenyi G, Hall B, Yu R, etal . Hook2 localizes to the centrosome, binds directly to centriolin/CEP110 and contributes to centrosomal function. . Traffic . 8 . 1 . 32–46 . 2007 . 17140400 . 10.1111/j.1600-0854.2006.00511.x . 19664393 .
• Simpson F, Martin S, Evans TM, etal . A novel hook-related protein family and the characterization of hook-related protein 1. . Traffic . 6 . 6 . 442–58 . 2005 . 15882442 . 10.1111/j.1600-0854.2005.00289.x . 25389776 . free .

Notes and References

1. Krämer H, Phistry M . Genetic analysis of hook, a gene required for endocytic trafficking in drosophila . Genetics . 151 . 2 . 675–84 . February 1999 . 10.1093/genetics/151.2.675 . 9927460 . 1460498 .
2. Walenta JH, Didier AJ, Liu X, Krämer H . The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins . J. Cell Biol. . 152 . 5 . 923–34 . March 2001 . 11238449 . 2198811 . 10.1083/jcb.152.5.923.
3. Web site: Entrez Gene: hook homolog 2 (Drosophila).