HOOK1 explained

Protein Hook homolog 1 is a protein that in humans is encoded by the HOOK1 gene.^{[1] [2]}

Function

This gene encodes a member of the hook family of coiled coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interacts with several members of the Rab GTPase family involved in endocytosis. It is thought to link endocytic membrane trafficking to the microtubule cytoskeleton. Several alternatively spliced transcript variants have been identified, but the full-length nature of some of these variants has not been determined.^[2]

Further reading

• Walenta JH, Didier AJ, Liu X, Krämer H . The Golgi-Associated Hook3 Protein Is a Member of a Novel Family of Microtubule-Binding Proteins . J. Cell Biol. . 152 . 5 . 923–34 . 2001 . 11238449 . 10.1083/jcb.152.5.923 . 2198811 .
• Mendoza-Lujambio I, Burfeind P, Dixkens C, etal . The Hook1 gene is non-functional in the abnormal spermatozoon head shape (azh) mutant mouse . Hum. Mol. Genet. . 11 . 14 . 1647–58 . 2003 . 12075009 . 10.1093/hmg/11.14.1647 . free . 10.1.1.490.653 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Luiro K, Yliannala K, Ahtiainen L, etal . Interconnections of CLN3, Hook1 and Rab proteins link Batten disease to defects in the endocytic pathway . Hum. Mol. Genet. . 13 . 23 . 3017–27 . 2005 . 15471887 . 10.1093/hmg/ddh321 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Weimer JM, Chattopadhyay S, Custer AW, Pearce DA . Elevation of Hook1 in a disease model of Batten disease does not affect a novel interaction between Ankyrin G and Hook1 . Biochem. Biophys. Res. Commun. . 330 . 4 . 1176–81 . 2005 . 15823567 . 10.1016/j.bbrc.2005.03.103 .
• Simpson F, Martin S, Evans TM, etal . A novel hook-related protein family and the characterization of hook-related protein 1 . Traffic . 6 . 6 . 442–58 . 2005 . 15882442 . 10.1111/j.1600-0854.2005.00289.x . 25389776 . free .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Gregory SG, Barlow KF, McLay KE, etal . The DNA sequence and biological annotation of human chromosome 1 . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . free .
• Beausoleil SA, Villén J, Gerber SA, etal . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .
• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein–protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .

Notes and References

1. Kramer H, Phistry M . Genetic analysis of hook, a gene required for endocytic trafficking in drosophila . Genetics . 151 . 2 . 675–84 . Mar 1999 . 10.1093/genetics/151.2.675 . 9927460 . 1460498 .
2. Web site: Entrez Gene: HOOK1 hook homolog 1 (Drosophila).