HOMER2 explained

Homer protein homolog 2 is a protein that in humans is encoded by the HOMER2 gene.^{[1] [2] [3]}

This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein may be involved in cell growth. Four transcript variants encoding distinct isoforms have been identified for this gene.

Interactions

HOMER2 has been shown to interact with RYR1.^[4]

See also

• HOMER1
• HOMER3

Further reading

• Soloviev MM, Ciruela F, Chan WY, McIlhinney RA . Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing. . J. Mol. Biol. . 295 . 5 . 1185–200 . 2000 . 10653696 . 10.1006/jmbi.1999.3436 .
• Feng W, Tu J, Yang T, etal . Homer regulates gain of ryanodine receptor type 1 channel complex. . J. Biol. Chem. . 277 . 47 . 44722–30 . 2003 . 12223488 . 10.1074/jbc.M207675200 . free .
• Kim JT, Park SH, Kim SK, etal . Potential role of Homer-2a on cutaneous vascular anomaly. . J. Korean Med. Sci. . 17 . 5 . 636–40 . 2003 . 10.3346/jkms.2002.17.5.636 . 12378015 . 3054924.
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Shiraishi Y, Mizutani A, Mikoshiba K, Furuichi T . Coincidence in dendritic clustering and synaptic targeting of homer proteins and NMDA receptor complex proteins NR2B and PSD95 during development of cultured hippocampal neurons. . Mol. Cell. Neurosci. . 22 . 2 . 188–201 . 2003 . 12676529 . 10.1016/S1044-7431(03)00037-X . 38323844 .
• Rong R, Ahn JY, Huang H, etal . PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis. . Nat. Neurosci. . 6 . 11 . 1153–61 . 2003 . 14528310 . 10.1038/nn1134 . 807407 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Ishibashi T, Ogawa S, Hashiguchi Y, etal . A novel protein specifically interacting with Homer2 regulates ubiquitin-proteasome systems. . J. Biochem. . 137 . 5 . 617–23 . 2005 . 15944415 . 10.1093/jb/mvi074 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Dahl JP, Kampman KM, Oslin DW, etal . Association of a polymorphism in the Homer1 gene with cocaine dependence in an African American population. . Psychiatr. Genet. . 15 . 4 . 277–83 . 2006 . 16314758 . 10.1097/00041444-200512000-00010 . 24128233 .

Notes and References

1. Tu JC, Xiao B, Yuan JP, Lanahan AA, Leoffert K, Li M, Linden DJ, Worley PF . Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors . Neuron . 21 . 4 . 717–26 . Dec 1998 . 9808459 . 10.1016/S0896-6273(00)80589-9 . free .
2. Xiao B, Tu JC, Petralia RS, Yuan JP, Doan A, Breder CD, Ruggiero A, Lanahan AA, Wenthold RJ, Worley PF . Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins . Neuron . 21 . 4 . 707–16 . Dec 1998 . 9808458 . 10.1016/S0896-6273(00)80588-7 . free .
3. Web site: Entrez Gene: HOMER2 homer homolog 2 (Drosophila).
4. Feng . Wei . Tu Jiancheng . Yang Tianzhong . Vernon Patty Shih . Allen Paul D . Worley Paul F . Pessah Isaac N . Nov 2002 . Homer regulates gain of ryanodine receptor type 1 channel complex . J. Biol. Chem. . 277 . 47 . 44722–30 . United States. 0021-9258. 12223488 . 10.1074/jbc.M207675200 . free .