1-Hydroxy-7-azabenzotriazole explained

1-Hydroxy-7-azabenzotriazole (HOAt) is a triazole used as a peptide coupling reagent.[1] It suppresses racemization that can otherwise occur during the reaction.[2] HOAt has a melting point between 213 and 216 degrees Celsius.[3] As a liquid, it is transparent and without any color.

Notes and References

  1. 10.1021/ja00063a082. 1-Hydroxy-7-azabenzotriazole. An efficient peptide coupling additive. Journal of the American Chemical Society. 115. 10. 4397–4398. 1993. Carpino. Louis A.
  2. Amide bond formation: beyond the myth of coupling reagents. Valeur. Eric. Bradley. Mark. Chemical Society Reviews. 2009. 38. 2. 606–631. 10.1039/b701677h. 19169468.
  3. Web site: HOAt. Chemical Book. January 30, 2019.

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