HNRPH2 explained

Heterogeneous nuclear ribonucleoprotein H2 is a protein that in humans is encoded by the HNRNPH2 gene.^{[1] [2]}

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that binds to RNAs. It is very similar to the family member HNRPH1. This gene is thought to be involved in Fabry disease and X-linked agammaglobulinemia phenotype. Alternative splicing results in multiple transcript variants encoding the same protein.^[3]

Further reading

• Vorechovský I, Vetrie D, Holland J, etal . Isolation of cosmid and cDNA clones in the region surrounding the BTK gene at Xq21.3-q22 . Genomics . 21 . 3 . 517–24 . 1994 . 7959728 . 10.1006/geno.1994.1310 .
• Vetrie D, Vorechovský I, Sideras P, etal . The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases . Nature . 361 . 6409 . 226–33 . 1993 . 8380905 . 10.1038/361226a0 . 1993Natur.361..226V . 42737818 .
• Tsukada S, Saffran DC, Rawlings DJ, etal . Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia . Cell . 72 . 2 . 279–90 . 1993 . 8425221 . 10.1016/0092-8674(93)90667-F . 32339052 .
• Oeltjen JC, Malley TM, Muzny DM, etal . Large-scale comparative sequence analysis of the human and murine Bruton's tyrosine kinase loci reveals conserved regulatory domains . Genome Res. . 7 . 4 . 315–29 . 1997 . 9110171 . 10.1101/gr.7.4.315. free .
• Honoré B, Vorum H, Baandrup U . hnRNPs H, H' and F behave differently with respect to posttranslational cleavage and subcellular localization . FEBS Lett. . 456 . 2 . 274–80 . 1999 . 10456323 . 10.1016/S0014-5793(99)00911-4 . free .
• Zhang Y, Lindblom T, Chang A, etal . Evidence that dim1 associates with proteins involved in pre-mRNA splicing, and delineation of residues essential for dim1 interactions with hnRNP F and Npw38/PQBP-1 . Gene . 257 . 1 . 33–43 . 2001 . 11054566 . 10.1016/S0378-1119(00)00372-3 .
• Caputi M, Zahler AM . Determination of the RNA binding specificity of the heterogeneous nuclear ribonucleoprotein (hnRNP) H/H'/F/2H9 family . J. Biol. Chem. . 276 . 47 . 43850–9 . 2001 . 11571276 . 10.1074/jbc.M102861200 . free .
• Shu H, Chen S, Bi Q, etal . Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line . Mol. Cell. Proteomics . 3 . 3 . 279–86 . 2004 . 14729942 . 10.1074/mcp.D300003-MCP200 . free .
• Bouwmeester T, Bauch A, Ruffner H, etal . A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway . Nat. Cell Biol. . 6 . 2 . 97–105 . 2004 . 14743216 . 10.1038/ncb1086 . 11683986 .
• Honoré B, Baandrup U, Vorum H . Heterogeneous nuclear ribonucleoproteins F and H/H' show differential expression in normal and selected cancer tissues . Exp. Cell Res. . 294 . 1 . 199–209 . 2004 . 14980514 . 10.1016/j.yexcr.2003.11.011 .
• Ross MT, Grafham DV, Coffey AJ, etal . The DNA sequence of the human X chromosome . Nature . 434 . 7031 . 325–37 . 2005 . 15772651 . 10.1038/nature03440 . 2665286 . 2005Natur.434..325R .
• Alkan SA, Martincic K, Milcarek C . The hnRNPs F and H2 bind to similar sequences to influence gene expression . Biochem. J. . 393 . Pt 1 . 361–71 . 2006 . 16171461 . 10.1042/BJ20050538 . 1383695 .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . free .

Notes and References

1. Honore B, Rasmussen HH, Vorum H, Dejgaard K, Liu X, Gromov P, Madsen P, Gesser B, Tommerup N, Celis JE . Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes . J Biol Chem . 270 . 48 . 28780–9 . Jan 1996 . 7499401 . 10.1074/jbc.270.48.28780 . free .
2. Web site: Entrez Gene: HNRPH2 heterogeneous nuclear ribonucleoprotein H2 (H').
3. Web site: Entrez Gene: HNRPH2 heterogeneous nuclear ribonucleoprotein H2 (H').