HNRNPAB explained

Heterogeneous nuclear ribonucleoprotein A/B, also known as HNRNPAB, is a protein which in humans is encoded by the HNRNPAB gene.^[1] Although this gene is named HNRNPAB in reference to its first cloning as an RNA binding protein with similarity to HNRNP A and HNRNP B,^[2] it is not a member of the HNRNP A/B subfamily of HNRNPs, but groups together closely with HNRNPD/AUF1 and HNRNPDL.^{[3] [4]}

Function

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.^[1]

Interactions

HNRNPAB has been shown to interact with TP63.^[5]

Further reading

• Khan FA, Jaiswal AK, Szer W . Cloning and sequence analysis of a human type A/B hnRNP protein . FEBS Letters . 290 . 1–2 . 159–61 . September 1991 . 1717314 . 10.1016/0014-5793(91)81249-8 . 11348906 . free .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . January 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Gress TM, Müller-Pillasch F, Geng M, Zimmerhackl F, Zehetner G, Friess H, Büchler M, Adler G, Lehrach H . A pancreatic cancer-specific expression profile . Oncogene . 13 . 8 . 1819–30 . October 1996 . 8895530 .
• Lau PP, Zhu HJ, Nakamuta M, Chan L . Cloning of an Apobec-1-binding protein that also interacts with apolipoprotein B mRNA and evidence for its involvement in RNA editing . The Journal of Biological Chemistry . 272 . 3 . 1452–5 . January 1997 . 8999813 . 10.1074/jbc.272.3.1452 . free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . October 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Hay DC, Kemp GD, Dargemont C, Hay RT . Interaction between hnRNPA1 and IkappaBalpha is required for maximal activation of NF-kappaB-dependent transcription . Molecular and Cellular Biology . 21 . 10 . 3482–90 . May 2001 . 11313474 . 100270 . 10.1128/MCB.21.10.3482-3490.2001 .
• Lau PP, Chang BH, Chan L . Two-hybrid cloning identifies an RNA-binding protein, GRY-RBP, as a component of apobec-1 editosome . Biochemical and Biophysical Research Communications . 282 . 4 . 977–83 . April 2001 . 11352648 . 10.1006/bbrc.2001.4679 .
• Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI . Directed proteomic analysis of the human nucleolus . Current Biology . 12 . 1 . 1–11 . January 2002 . 11790298 . 10.1016/S0960-9822(01)00650-9 . 14132033 . free . 2002CBio...12....1A .
• Percipalle P, Jonsson A, Nashchekin D, Karlsson C, Bergman T, Guialis A, Daneholt B . Nuclear actin is associated with a specific subset of hnRNP A/B-type proteins . Nucleic Acids Research . 30 . 8 . 1725–34 . April 2002 . 11937625 . 113215 . 10.1093/nar/30.8.1725 .
• Angenstein F, Evans AM, Settlage RE, Moran ST, Ling SC, Klintsova AY, Shabanowitz J, Hunt DF, Greenough WT . A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons . The Journal of Neuroscience . 22 . 20 . 8827–37 . October 2002 . 12388589 . 10.1523/jneurosci.22-20-08827.2002. 6757688 . free .
• Fomenkov A, Huang YP, Topaloglu O, Brechman A, Osada M, Fomenkova T, Yuriditsky E, Trink B, Sidransky D, Ratovitski E . P63 alpha mutations lead to aberrant splicing of keratinocyte growth factor receptor in the Hay-Wells syndrome . The Journal of Biological Chemistry . 278 . 26 . 23906–14 . June 2003 . 12692135 . 10.1074/jbc.M300746200 . free .
• Zhang S, Schlott B, Görlach M, Grosse F . DNA-dependent protein kinase (DNA-PK) phosphorylates nuclear DNA helicase II/RNA helicase A and hnRNP proteins in an RNA-dependent manner . Nucleic Acids Research . 32 . 1 . 1–10 . 2004 . 14704337 . 373260 . 10.1093/nar/gkg933 .
• Ong SE, Mittler G, Mann M . Identifying and quantifying in vivo methylation sites by heavy methyl SILAC . Nature Methods . 1 . 2 . 119–26 . November 2004 . 15782174 . 10.1038/nmeth715 . 6654604 .
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nature Biotechnology . 24 . 10 . 1285–92 . October 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .

Notes and References

1. Web site: HNRNPAB heterogeneous nuclear ribonucleoprotein A/B [Homo sapiens (human) ]].
2. Khan FA, Jaiswal AK, Szer W . Cloning and sequence analysis of a human type A/B hnRNP protein . FEBS Letters . 290 . 1–2 . 159–61 . September 1991 . 1717314 . 10.1016/0014-5793(91)81249-8 . 11348906 . free .
3. Akindahunsi AA, Bandiera A, Manzini G . Vertebrate 2xRBD hnRNP proteins: a comparative analysis of genome, mRNA and protein sequences . Computational Biology and Chemistry . 29 . 1 . 13–23 . February 2005 . 15680582 . 10.1016/j.compbiolchem.2004.11.002 .
4. Czaplinski K, Köcher T, Schelder M, Segref A, Wilm M, Mattaj IW . Identification of 40LoVe, a Xenopus hnRNP D family protein involved in localizing a TGF-beta-related mRNA during oogenesis . Developmental Cell . 8 . 4 . 505–15 . April 2005 . 15809033 . 10.1016/j.devcel.2005.01.012 . free .
5. Fomenkov A, Huang YP, Topaloglu O, Brechman A, Osada M, Fomenkova T, Yuriditsky E, Trink B, Sidransky D, Ratovitski E . P63 alpha mutations lead to aberrant splicing of keratinocyte growth factor receptor in the Hay-Wells syndrome . The Journal of Biological Chemistry . 278 . 26 . 23906–14 . June 2003 . 12692135 . 10.1074/jbc.M300746200 . free .