HNRNPA0 explained

Heterogeneous nuclear ribonucleoprotein A0 is a protein that in humans is encoded by the HNRNPA0 gene.^{[1] [2]}

This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind RNAs, followed by a glycine-rich C-terminus.^[2]

Further reading

• Dawson SJ, White LA . Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. . J. Infect. . 24 . 3 . 317–20 . 1992 . 1602151 . 10.1016/S0163-4453(05)80037-4 .
• Cross SH, Charlton JA, Nan X, Bird AP . Purification of CpG islands using a methylated DNA binding column. . Nat. Genet. . 6 . 3 . 236–44 . 1994 . 8012384 . 10.1038/ng0394-236 . 12847618 .
• Li SH, McInnis MG, Margolis RL, etal . Novel triplet repeat containing genes in human brain: cloning, expression, and length polymorphisms. . Genomics . 16 . 3 . 572–9 . 1993 . 8325628 . 10.1006/geno.1993.1232 . free .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Hillier LD, Lennon G, Becker M, etal . Generation and analysis of 280,000 human expressed sequence tags. . Genome Res. . 6 . 9 . 807–28 . 1997 . 8889549 . 10.1101/gr.6.9.807 . free .
• Lai F, Godley LA, Joslin J, etal . Transcript map and comparative analysis of the 1.5-Mb commonly deleted segment of human 5q31 in malignant myeloid diseases with a del(5q). . Genomics . 71 . 2 . 235–45 . 2001 . 11161817 . 10.1006/geno.2000.6414 .
• Rousseau S, Morrice N, Peggie M, etal . Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs. . EMBO J. . 21 . 23 . 6505–14 . 2003 . 12456657 . 10.1093/emboj/cdf639 . 136943 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Rush J, Moritz A, Lee KA, etal . Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. . Nat. Biotechnol. . 23 . 1 . 94–101 . 2005 . 15592455 . 10.1038/nbt1046 . 7200157 .
• Andersen JS, Lam YW, Leung AK, etal . Nucleolar proteome dynamics. . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . 2005Natur.433...77A . 4344740 .
• Ong SE, Mittler G, Mann M . Identifying and quantifying in vivo methylation sites by heavy methyl SILAC. . Nat. Methods . 1 . 2 . 119–26 . 2005 . 15782174 . 10.1038/nmeth715 . 6654604 .

Notes and References

1. Myer VE, Steitz JA . Isolation and characterization of a novel, low abundance hnRNP protein: A0 . RNA . 1 . 2 . 171–82 . Dec 1995 . 7585247 . 1369071 .
2. Web site: Entrez Gene: HNRPA0 heterogeneous nuclear ribonucleoprotein A0.