HMG20B explained

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related is a protein that in humans is encoded by the HMG20B gene.^{[1] [2]}

HMG20B is a high-mobility group (HMG) DNA binding protein. HMG20B contains a carboxy terminal region that is essential for cytokinesis since it regulates cell cycle progression from the G2 phase into mitosis^[3] This carboxy terminal region of HMG20B interacts with the tumor suppressor protein BRCA2. A particular mutation in this region of the HMG20B gene is associated with lung cancer. This mutation interferes with the association of the HMG20B and BRCA2 proteins.^[3]

Interactions

HMG20B has been shown to interact with:

• BRCA2,^[4]
• HDAC1,^[5]
• HDAC2,^{[5] [6]}
• KIF4A,^[7]
• PHF21A,^{[5] [8]} and
• RCOR1.^[5]

Further reading

• Wattler F, Wattler S, Kelly M, Skinner HB, Nehls M . Cloning, chromosomal location, and expression analysis of murine Smarce1-related, a new member of the high-mobility 365 group gene family . Genomics . 60 . 2 . 172–8 . September 1999 . 10486208 . 10.1006/geno.1999.5913 .
• Marmorstein LY, Kinev AV, Chan GK, Bochar DA, Beniya H, Epstein JA, Yen TJ, Shiekhattar R . A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression . Cell . 104 . 2 . 247–57 . January 2001 . 11207365 . 10.1016/S0092-8674(01)00209-4 . 5822368 . free .
• Lee YM, Shin H, Choi W, Ahn S, Kim W . Characterization of human SMARCE1r high-mobility-group protein . Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression . 1574 . 3 . 269–76 . April 2002 . 11997092 . 10.1016/s0167-4781(01)00373-6 .
• Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R . A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes . Proceedings of the National Academy of Sciences of the United States of America . 99 . 11 . 7420–5 . May 2002 . 12032298 . 124246 . 10.1073/pnas.112008599 . 2002PNAS...99.7420H . free .
• Wang C, McCarty IM, Balazs L, Li Y, Steiner MS . Cloning a cDNA encoding an alternatively spliced protein of BRCA2-associated factor 35 . Biochemical and Biophysical Research Communications . 295 . 1 . 129–35 . July 2002 . 12083779 . 10.1016/S0006-291X(02)00624-1 .
• Wang C, McCarty IM, Balazs L, Li Y, Steiner MS . Immunohistological detection of BRAF25 in human prostate tumor and cancer specimens . Biochemical and Biophysical Research Communications . 295 . 1 . 136–41 . July 2002 . 12083780 . 10.1016/S0006-291X(02)00625-3 .
• Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R . A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes . The Journal of Biological Chemistry . 278 . 9 . 7234–9 . February 2003 . 12493763 . 10.1074/jbc.M208992200 . free.
• Lee YM, Kim W . Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35 . The Biochemical Journal . 374 . Pt 2 . 497–503 . September 2003 . 12809554 . 1223617 . 10.1042/BJ20030452 .
• Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T . Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression . Biochemical and Biophysical Research Communications . 322 . 2 . 601–8 . September 2004 . 15325272 . 10.1016/j.bbrc.2004.07.163 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . October 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Sumoy L, Carim L, Escarceller M, Nadal M, Gratacòs M, Pujana MA, Estivill X, Peral B . HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and constitute a distinct class of HMG-box genes with ubiquitous expression . Cytogenetics and Cell Genetics . 88 . 1–2 . 62–7 . Jun 2000 . 10773667 . 10.1159/000015486 . 22921110 .
2. Web site: Entrez Gene: HMG20B high-mobility group 20B.
3. Lee M, Venkitaraman AR . A cancer-associated mutation inactivates a region of the high-mobility group protein HMG20b essential for cytokinesis . Cell Cycle . 13 . 16 . 2554–63 . 2014 . 25486196 . 4614378 . 10.4161/15384101.2014.942204 .
4. Marmorstein LY, Kinev AV, Chan GK, Bochar DA, Beniya H, Epstein JA, Yen TJ, Shiekhattar R . A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression . Cell . 104 . 2 . 247–57 . January 2001 . 11207365 . 10.1016/S0092-8674(01)00209-4 . 5822368 . free .
5. Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R . A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes . Proceedings of the National Academy of Sciences of the United States of America . 99 . 11 . 7420–5 . May 2002 . 12032298 . 124246 . 10.1073/pnas.112008599 . 2002PNAS...99.7420H . free .
6. Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R . A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes . The Journal of Biological Chemistry . 278 . 9 . 7234–9 . February 2003 . 12493763 . 10.1074/jbc.M208992200 . free.
7. Lee YM, Kim W . Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35 . The Biochemical Journal . 374 . Pt 2 . 497–503 . September 2003 . 12809554 . 1223617 . 10.1042/BJ20030452 .
8. Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T . Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression . Biochemical and Biophysical Research Communications . 322 . 2 . 601–8 . September 2004 . 15325272 . 10.1016/j.bbrc.2004.07.163 .