HMCES explained
5-hydroxymethylcytosine binding, ES cell specific is a protein that in humans is encoded by the HMCES gene.[1]
Further reading
- Coppieters N, Dieriks BV, Lill C, Faull RL, Curtis MA, Dragunow M . Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain . Neurobiol. Aging . 35 . 6 . 1334–44 . June 2014 . 24387984 . 10.1016/j.neurobiolaging.2013.11.031 . 25277574 .
- Condliffe D, Wong A, Troakes C, Proitsi P, Patel Y, Chouliaras L, Fernandes C, Cooper J, Lovestone S, Schalkwyk L, Mill J, Lunnon K . Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain . Neurobiol. Aging . 35 . 8 . 1850–4 . August 2014 . 24679604 . 4066184 . 10.1016/j.neurobiolaging.2014.02.002 .
- Kraus TF, Guibourt V, Kretzschmar HA . 5-Hydroxymethylcytosine, the "Sixth Base", during brain development and ageing . J Neural Transm (Vienna) . 122 . 7 . 1035–43 . July 2015 . 25471351 . 10.1007/s00702-014-1346-4 . 34905929 .
- Zhang LY, Li PL, Wang TZ, Zhang XC . Prognostic values of 5-hmC, 5-mC and TET2 in epithelial ovarian cancer . Arch. Gynecol. Obstet. . 292 . 4 . 891–7 . October 2015 . 25827305 . 10.1007/s00404-015-3704-3 . 24483457 .
- Biayna . Josep . Garcia-Cao . Isabel . Álvarez . Miguel M. . Salvadores . Marina . Espinosa-Carrasco . Jose . McCullough . Marcel . Supek . Fran . Stracker . Travis H. . Loss of the abasic site sensor HMCES is synthetic lethal with the activity of the APOBEC3A cytosine deaminase in cancer cells . PLOS Biology . 2021-03-31 . 19 . 3 . e3001176 . 10.1371/journal.pbio.3001176. 33788831 . 8041192 . free .
Notes and References
- Web site: Entrez Gene: 5-hydroxymethylcytosine binding, ES cell specific. 2018-05-16.