HLA-DR8 explained

human major histocompatibility complex, class II, DR8
Haplotypes groups	DQA*01:DRB1*0801 toDQA*01:DRB1*0806
Structure (See HLA-DR)
Identifiers	alpha *0101
Symbol(s)	HLA-DRA
EBI-HLA	DRA*0101
Identifiers	beta 1 *0801 to *0806
Symbol(s)	HLA-DRB1
EBI-HLA	DRB1*0801
EBI-HLA	DRB1*0802
EBI-HLA	DRB1*0803
EBI-HLA	DRB1*0804
EBI-HLA	DRB1*0805
EBI-HLA	DRB1*0806
Shared data
Locus	chr.6 6p21.31

HLA-DR8 (DR8) is a HLA-DR serotype that recognizes the DRB1*0801 to *0807, and *0810 to *0812 gene products.

Serology

DR8 serological recognition of the gene products of some DRB1*08 alleles^[1]

DRB1*	DR8	Sample
allele	%	size (N)
0801	95	1076
0802	96	265
0803	88	230^[2]
0804	93	186
0805	>60	5
0806	>75	13

The serological reaction of DR8 is relatively good. The serology of DRB1*0808, *0809 and *0813 to *0832 serotypes is unknown.

Disease associations

DR8 is linked to papillary thyroid carcinomas,^[3] early onset pauciarticular juvenile chronic arthritis,^{[4] [5]} primary biliary cirrhosis^[6]

by allele

HLA-DRB1*0801 is linked to primary biliary cirrhosis^[7] In Mexicans DR8 is found more often in type-2 juvenile diabetes.^[8]

HLA-DRB1*0803 is also linked to primary biliary cirrhosis^[7]

Genetic Linkage

DR8 Haplotypes
	DRA	DRB1
Haplotypes	0101	0801	0101
	DQA1	DQB1	DRB1
Haplotypes	0401	0402	0801
	HLA-A	HLA-B	DRB1
Haplotypes	0000	0000	0801

HLA-DR8 is not genetically linked to HLA-DR51 to DR53, but is linked to DQ4 serotypes.

Notes and References

1. http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA
2. DR12 - 3%
3. Porto T, Coelho I, Boavida J, Pereira C, Nunes J, Mendonça D, Martins B, Sobrinho L, Leite V . Association of HLA DQ4-DR8 haplotype with papillary thyroid carcinomas. . Clin Endocrinol . 64 . 2 . 179–83 . 2006 . 16430717 . 10.1111/j.1365-2265.2006.02445.x. 22695710 .
4. Haas J, Truckenbrodt H, Paul C, Hoza J, Scholz S, Albert E . Subtypes of HLA-DRB1*03, *08, *11, *12, *13 and *14 in early onset pauciarticular juvenile chronic arthritis (EOPA) with and without iridocyclitis. . Clin Exp Rheumatol . 12 . S7–14 . 1994. Suppl 10 . 7955632.
5. Säilä H, Pitkäniemi J, Tuomilehto J, Savolainen A, Alakulppi N, Tuomilehto-Wolf E, Leirisalo-Repo M, Aho K . HLA and susceptibility to juvenile idiopathic arthritis: a study of affected sibpairs in an isolated Finnish population. . J Rheumatol . 31 . 11 . 2281–5 . 2004 . 15517645.
6. Underhill J, Donaldson P, Bray G, Doherty D, Portmann B, Williams R . Susceptibility to primary biliary cirrhosis is associated with the HLA-DR8-DQB1*0402 haplotype. . Hepatology . 16 . 6 . 1404–8 . 1992 . 1359995 . 10.1002/hep.1840160616. 7200339 . free .
7. Charatcharoenwitthaya P, Lindor K . Current concepts in the pathogenesis of primary biliary cirrhosis. . Ann Hepatol . 4 . 3 . 161–75 . 2005. 10.1016/S1665-2681(19)32061-7 . 16177655. free .
8. Rodríguez-Ventura AL, Yamamoto-Furusho JK, Coyote N, etal . HLA-DRB1*08 allele may help to distinguish between type 1 diabetes mellitus and type 2 diabetes mellitus in Mexican children . . 8 . 1 . 5–10 . 2007 . 17341285 . 10.1111/j.1399-5448.2006.00221.x. 35352151 . free .