HLA-DR51 explained

major histocompatibility complex, class II, DR51
Haplotypes groups	DRA*01:DRB5*01 DRA*01:DRB5*02
Structure (See HLA-DR)
Identifiers	alpha *0101
Symbol(s)	HLA-DRA
EBI-HLA	DRA*0101
Identifiers	beta 5 *01 *02
Symbol(s)	HLA-DRB5
EBI-HLA	DRB5*01
EBI-HLA	DRB5*02
Shared data
Locus	chr.6 6p21.31

HLA-DR51 is a HLA-DR serotype that recognizes the antigens encoded by the minor DR locus HLA-DRB5.

DRB3, DRB4, and DRB5 are minor DR beta encoding loci, they have been recognized as having distinct evolution,^[1] having diverged from DRB1 approximately 4 million years ago.^[2]

DRB5 locus is only apparent in a small subset of DR haplotypes, and most individuals lack DRB5.

Alleles

DR52 recognition of some DRB3* alleles^[3]

DRB5*	DR51	?	Sample
allele	%	%	size (N)
0101	>71		28
0102	>86		8
0202	>86		13

DRB5* is subdivided into two allele groups, DRB5*01 and DRB5*02. B5*01 encodes 14 alleles and 11 isoforms. B5*02 encoded 4 alleles that can generate 4 isoforms. Only 3 of these have been surveyed by serotyping. There are numerous null genes at this locus.

DRB5*01 allele group

• 14 Alleles: 11 proteins, 2 Nulls
• DR51 Serotype: *0101, *0102
• Serotype unknown: *0103 to *0107, *0109, *0110 to *0113
• Nulls: *0108N, *0110N

DRB5*02 allele group

• 4 Alleles: 4 proteins
• DR51 Serotype: *0202,
• Serotype unknown: *0203 to *0205

Associated diseases

DR51 serotype is positively associated with The following HLA-DRB5 alleles are associated with disease:

DRB5*0101:DRB1*1501 Multiple sclerosis,^[4] leprosy^[5]

DRB1 linkage

HLA-DRB5 (DR51)is linked to the following HLA-DR serotypes and DRB1 allele groups.

HLA-DR2

• HLA-DR15 - DRB1*15
• HLA-DR16 - DRB1*16

Notes and References

1. Gorski J, Rollini P, Mach B . Structural comparison of the genes of two HLA-DR supertypic groups: the loci encoding DRw52 and DRw53 are not truly allelic . Immunogenetics . 25 . 6 . 397–402 . 1987 . 3596674 . 10.1007/BF00396106. 25853147 .
2. Gongora R, Figueroa F, Klein J . The HLA-DRB9 gene and the origin of HLA-DR haplotypes . Hum. Immunol. . 51 . 1 . 23–31 . 1996 . 8911994 . 10.1016/S0198-8859(96)00189-9 . free .
3. http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA
4. Sospedra M, Muraro P, Stefanová I, Zhao Y, Chung K, Li Y, Giulianotti M, Simon R, Mariuzza R, Pinilla C, Martin R . Redundancy in antigen-presenting function of the HLA-DR and -DQ molecules in the multiple sclerosis-associated HLA-DR2 haplotype. . J Immunol . 176 . 3 . 1951–61 . 2006 . 16424227 . 2746197 . 10.4049/jimmunol.176.3.1951.
5. Joko S, Numaga J, Kawashima H, Namisato M, Maeda H . Human leukocyte antigens in forms of leprosy among Japanese patients. . Int J Lepr Other Mycobact Dis . 68 . 1 . 49–56 . 2000 . 10834069.