HLA-DR14 explained


major histocompatibility complex, class II, DR14
Haplotypes groups	DRA01:DRB11401 DRA01:DRB11402 DRA01:DRB11403 DRA01:DRB11404 ....
Structure (See HLA-DR)
Identifiers	alpha *0101
Symbol(s)	HLA-DRA
EBI-HLA	DRA*0101
Identifiers	beta 1 1401 to 1408 *1410
Symbol(s)	HLA-DRB1
EBI-HLA	DRB1*1401
EBI-HLA	DRB1*1402
EBI-HLA	DRB1*1403
EBI-HLA	DRB1*1404
EBI-HLA	DRB1*1405
EBI-HLA	DRB1*1406
Shared data
Locus	chr.6 6p21.31

HLA-DR14(DR14) is a HLA-DR serotype that recognizes the DRB1*1401 to *1408, *1410 to *1418, and other *14 gene products. DR14 serotype is a split antigen of the older HLA-DR6 serotype group which also contains the similar HLA-DR13 antigens.

Alleles

DR14, DR6 and other serotype recognition of some DRB1*14 alleles^[1]
DRB1*	DR14	DR6	DR13	Sample
allele	%	%	%	size (N)
1401	74	14	3	1942
1402	61	13	9	204
1403	72	12	2	37
1404	79	8		80^[2]
1405	86	10		58
1406	37	15	22	117
1407	90			10
1408	25			4^[3]
1410	>75			4

Serotypes are unknown the following alleles: DRB1**1409, *1419 to *1462

Disease associations

DRB1*1402: juvenile rheumatoid arthritis,^[4] increased longevity in Okinawans.

Extended linkage

DR*14:DQ5 haplotype: increased risk for non-AChR autoantibodies in myasthenia gravis.^[5]

Genetic Linkage

DR14 Haplotypes
	DRA	DRB1	DRB3
DR14(6)-DR52	0101	1401	0201
	0101	1402	0201
	0101	1403	0101
	DQA1	DQB1	DRB1
DR14-DQ5(5.3, 1)	0104	0503	1401
	HLA-A	HLA-B	DRB1
A11-B35-DR14(6)	1101	3501	1401
A2-B51(5)-DR14(6)	0201	5101	1401

HLA-DR13 is genetically linked to HLA-DR52^[6] and HLA-DQ5 (HLA-DQ1) serotypes.

Notes and References

http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA
DR1404 - 3%
DR4 - 25%
Garavito G, Yunis E, Egea E, Ramirez L, Malagón C, Iglesias A, De La Cruz O, Uribe O, Navarro E, Martinez P, Jaraquemada D . HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos. . Hum Immunol . 65 . 4 . 359–65 . 2004 . 15120191 . 10.1016/j.humimm.2004.01.016.
Niks EH, Kuks JB, Roep BO, etal . Strong association of MuSK antibody-positive myasthenia gravis and HLA-DR14-DQ5 . Neurology . 66 . 11 . 1772–4 . 2006 . 16769963 . 10.1212/01.wnl.0000218159.79769.5c. 41206495 .
Song EY, Park H, Roh EY, Park MH . HLA-DRB1 and -DRB3 allele frequencies and haplotypic associations in Koreans . Hum. Immunol. . 65 . 3 . 270–6 . 2004 . 15041167 . 10.1016/j.humimm.2003.12.005.