HLA-DQB2 explained

HLA class II histocompatibility antigen, DX beta chain is a protein that in humans is encoded by the HLA-DQB2 gene.^{[1] [2]}

Further reading

• Piatier-Tonneau D . Interaction of CD4 with HLA class II antigens and HIV gp120 . Immunogenetics . 34 . 2 . 121–8 . 1991 . 1869305 . 10.1007/BF00211424 . vanc. Gastinel LN . Amblard F . 3 . Wojcik . Marianne . Vaigot . Pierre . Auffray . Charles . 10116507 .
• Rosenstein Y, Burakoff SJ, Herrmann SH . HIV-gp120 can block CD4-class II MHC-mediated adhesion . J. Immunol. . 144 . 2 . 526–31 . 1990 . 10.4049/jimmunol.144.2.526 . 1967269 . 23550626 . free .
• Bowman MR, MacFerrin KD, Schreiber SL, Burakoff SJ . Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules . Proc. Natl. Acad. Sci. U.S.A. . 87 . 22 . 9052–6 . 1991 . 1978941 . 10.1073/pnas.87.22.9052 . 55099 . free .
• Clayton LK, Sieh M, Pious DA, Reinherz EL . Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding . Nature . 339 . 6225 . 548–51 . 1989 . 2543930 . 10.1038/339548a0 . 1989Natur.339..548C . 4246781 . free .
• Diamond DC . Inhibition of CD4+ T cell function by the HIV envelope protein, gp120 . J. Immunol. . 141 . 11 . 3715–7 . 1988 . 2846691 . vanc. Sleckman BP . Gregory T . 3 . Lasky . LA . Greenstein . JL . Burakoff . SJ . 10.4049/jimmunol.141.11.3715 . 2607172 . free.
• Jonsson AK . Class II genes of the human major histocompatibility complex. Comparisons of the DQ and DX alpha and beta genes . J. Biol. Chem. . 262 . 18 . 8767–77 . 1987 . 3036828 . vanc. Hyldig-Nielsen JJ . Servenius B . 3 . Larhammar . D . Andersson . G . Jörgensen . F . Peterson . PA . Rask . L . 10.1016/S0021-9258(18)47482-0 . free .
• Andrieu JM, Even P, Venet A . AIDS and related syndromes as a viral-induced autoimmune disease of the immune system: an anti-MHC II disorder. Therapeutic implications . AIDS Research . 2 . 3 . 163–74 . 1986 . 3489470 . 10.1089/aid.1.1986.2.163.
• Okada K . Gene organization of DC and DX subregions of the human major histocompatibility complex . Proc. Natl. Acad. Sci. U.S.A. . 82 . 10 . 3410–4 . 1985 . 3858830 . 10.1073/pnas.82.10.3410 . 397785 . vanc. Boss JM . Prentice H . 3 . Spies . T . Mengler . R . Auffray . C . Lillie . J . Grossberger . D . Strominger . JL . 1985PNAS...82.3410O . free .
• Houlgatte R . HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4 . J. Immunol. . 152 . 9 . 4475–88 . 1994 . 7512597 . vanc. Scarmato P . el Marhomy S . 3 . Martin . M . Ostankovitch . M . Lafosse . S . Vervisch . A . Auffray . C . Platier-Tonneau . D . 10.4049/jimmunol.152.9.4475 . 41283223 . free .
• Chirmule N . HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71) . J. Immunol. . 155 . 2 . 917–24 . 1995 . 7541827 . vanc. McCloskey TW . Hu R . 3 . Kalyanaraman . VS . Pahwa . S . 10.4049/jimmunol.155.2.917 . 8911033 . free .
• Rowell JF, Stanhope PE, Siliciano RF . Endocytosis of endogenously synthesized HIV-1 envelope protein. Mechanism and role in processing for association with class II MHC . J. Immunol. . 155 . 1 . 473–88 . 1995 . 10.4049/jimmunol.155.1.473 . 7602119 . 19994352 .
• Chen YH . HIV-1 gp41 binding proteins and antibodies to gp41 could inhibit enhancement of human Raji cell MHC class I and II expression by gp41 . Mol. Immunol. . 31 . 13 . 977–82 . 1994 . 8084338 . 10.1016/0161-5890(94)90092-2 . vanc. Böck G . Vornhagen R . 3 . Steindl . Franz . Katinger . Hermann . p. Dierich . Manfred .
• Chirmule N . Envelope glycoproteins of HIV-1 interfere with T-cell-dependent B cell differentiation: role of CD4-MHC class II interaction in the effector phase of T cell help . Cell. Immunol. . 155 . 1 . 169–82 . 1994 . 8168144 . 10.1006/cimm.1994.1110 . vanc. Wang XP . Hu R . 3 . Oyaizu . N . Roifman . C . Pahwa . R . Kalyanaraman . VS . Pahwa . S . free .
• Callahan KM . HIV-1 envelope protein is expressed on the surface of infected cells before its processing and presentation to class II-restricted T lymphocytes . J. Immunol. . 151 . 6 . 2928–42 . 1993 . 8376762 . vanc. Rowell JF . Soloski MJ . 3 . Machamer . CE . Siliciano . RF . 10.4049/jimmunol.151.6.2928 . 1391866 . free .
• Beck S . Evolutionary dynamics of non-coding sequences within the class II region of the human MHC . J. Mol. Biol. . 255 . 1 . 1–13 . 1996 . 8568858 . 10.1006/jmbi.1996.0001 . vanc. Abdulla S . Alderton RP . 3 . Glynne . RJ . Gut . IG . Hosking . LK . Jackson . A . Kelly . A . Newell . WR .
• Ruff AL . The enhanced immune response to the HIV gp160/LAMP chimeric gene product targeted to the lysosome membrane protein trafficking pathway . J. Biol. Chem. . 272 . 13 . 8671–8 . 1997 . 9079699 . 10.1074/jbc.272.13.8671 . vanc. Guarnieri FG . Staveley-O'Carroll K . 3 . Siliciano . RF . August . JT . free.
• Hsu SH . Identification of a new DQB1*0613 allele in a family . Tissue Antigens . 50 . 6 . 685–7 . 1998 . 9458130 . 10.1111/j.1399-0039.1997.tb02935.x . vanc. Robbins FM . Modelo RB . 3 . Brunner . J. . Flomenberg . N. .
• Kanazawa S, Okamoto T, Peterlin BM . Tat competes with CIITA for the binding to P-TEFb and blocks the expression of MHC class II genes in HIV infection . Immunity . 12 . 1 . 61–70 . 2000 . 10661406 . 10.1016/S1074-7613(00)80159-4 . free .
• Poon DT, Coren LV, Ott DE . Efficient incorporation of HLA class II onto human immunodeficiency virus type 1 requires envelope glycoprotein packaging . J. Virol. . 74 . 8 . 3918–23 . 2000 . 10729169 . 10.1128/JVI.74.8.3918-3923.2000 . 111903 .

Notes and References

1. Berdoz J, Tiercy JM, Rollini P, Mach B, Gorski J . Remarkable sequence conservation of the HLA-DQB2 locus (DX beta) within the highly polymorphic DQ subregion of the human MHC . Immunogenetics . 29 . 4 . 241–8 . May 1989 . 2564844 . 10.1007/BF00717908 . 8196719 .
2. Web site: Entrez Gene: HLA-DQB2 major histocompatibility complex, class II, DQ beta 2.