major histocompatibility complex, class II, DQ3 | |
Haplotypes | DQA1*0303:DQB1*0301 DQA1*0401:DQB1*0301 DQA1*0505:DQB1*0301 DQA1*0601:DQB1*0301 DQA1*03:DQB1*0302 DQA1*0301:DQB1*0303 |
Structure (See HLA-DQ) | |
Identifiers | alpha 1
|
Symbol(s) | HLA-DQA1 |
EBI-HLA | DQA1*0301 |
EBI-HLA | DQA1*0302 |
EBI-HLA | DQA1*0303 |
EBI-HLA | DQA1*0401 |
EBI-HLA | DQA1*0505 |
Identifiers | beta 1 *0301 *0302 *0303 |
Symbol(s) | HLA-DQB1 |
EBI-HLA | DQB1*0301 |
EBI-HLA | DQB1*0302 |
EBI-HLA | DQB1*0303 |
Shared data | |
Locus | chr.6 6p21.31 |
DQB1* | DQ7 | DQ3 | DQ8 | Sample |
allele | % | % | % | size (N) |
0301 | 85 | 40 | 1 | 12220 |
0304 | 40 | 35 | 8 | 111 |
. | ||||
DQ8 | DQ3 | DQ7 | N | |
0302 | 66 | 25 | 1 | 6657 |
0305 | 34 | 30 | 70 | |
DQ9 | DQ3 | DQ2 | N | |
0303 | 67 | 12 | 11 | |
DQ7 | DQ8 | N | ||
0303 | 1 | 1 | 2563 | |
The serotyping efficiency of DQ3 recognition relative to DQ2, DQ7, DQ8, and DQ9 is shown to the left. Compared to DQ2 serotyping of DQB1*0201 positive individuals (98%), the efficiency of DQ3 recognition is relatively low and error prone. This compares to genotyping efficiency of 100%. The recognition of DQB1*0303 by DQ9 and or DQ3 is poorest, DQ2 which recognizes a different DBB1*group recognizes DQB1*0303 as efficientlyas DQ3.
For this reason DQ3 serotyping is a poor method of typing for transplantation or disease association prediction or study.Nonetheless, it is still widely used and association purported in the literature.
DQB1*0301 the DQ7 gene, is detailed on HLA-DQ7
DQB1*0302 the DQ8 gene, is detailed on HLA-DQ8
DQB1*0303 the DQ9 gene, is detailed on HLA-DQ9
DQB1*0304 is similar in structure and function to DQB1*0301 generally considered to be HLA-DQ7
DQB1*0305 is similar in structure and function to DQB1*0302 generally considered to be HLA-DQ8