HLA-B associated transcript 3 explained

Large proline-rich protein BAT3 is a protein that in humans is encoded by the BAT3 gene.^{[1] [2]}

A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. The protein encoded by this gene is a nuclear protein. It has been implicated in the control of apoptosis and regulating heat shock protein. There are three alternatively spliced transcript variants described for this gene.

Further reading

• Takayama S, Reed JC . Molecular chaperone targeting and regulation by BAG family proteins . Nat. Cell Biol. . 3 . 10 . E237–41 . 2001 . 11584289 . 10.1038/ncb1001-e237 . 24466133 .
• Cross SJ, Tonks S, Trowsdale J, Campbell RD . Novel detection of restriction fragment length polymorphisms in the human major histocompatibility complex . Immunogenetics . 34 . 6 . 376–84 . 1992 . 1684176 . 10.1007/BF01787488 . 29262131 .
• Spies T, Bresnahan M, Strominger JL . Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B . Proc. Natl. Acad. Sci. U.S.A. . 86 . 22 . 8955–8 . 1989 . 2813433 . 10.1073/pnas.86.22.8955 . 298409 . 1989PNAS...86.8955S . free .
• Spies T . A new cluster of genes within the human major histocompatibility complex . Science . 243 . 4888 . 214–7 . 1989 . 2911734 . 10.1126/science.2911734 . vanc. Blanck G . Bresnahan M . 3 . Sands . J . Strominger . J. . 1989Sci...243..214S .
• Ozaki T . Cloning and characterization of rat BAT3 cDNA . DNA Cell Biol. . 18 . 6 . 503–12 . 1999 . 10390159 . 10.1089/104454999315222 . vanc. Hanaoka E . Naka M . 3 . Nakagawara . Akira . Sakiyama . Shigeru .
• Thress K, Song J, Morimoto RI, Kornbluth S . Reversible inhibition of Hsp70 chaperone function by Scythe and Reaper . EMBO J. . 20 . 5 . 1033–41 . 2001 . 11230127 . 10.1093/emboj/20.5.1033 . 145500 .
• Manchen ST, Hubberstey AV . Human Scythe contains a functional nuclear localization sequence and remains in the nucleus during staurosporine-induced apoptosis . Biochem. Biophys. Res. Commun. . 287 . 5 . 1075–82 . 2001 . 11587531 . 10.1006/bbrc.2001.5701 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Mungall AJ . The DNA sequence and analysis of human chromosome 6 . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . vanc. Palmer SA . Sims SK . 3 . Edwards . C. A. . Ashurst . J. L. . Wilming . L. . Jones . M. C. . Horton . R. . Hunt . S. E. . 2003Natur.425..805M . free .
• Xie T . Analysis of the Gene-Dense Major Histocompatibility Complex Class III Region and Its Comparison to Mouse . Genome Res. . 13 . 12 . 2621–36 . 2004 . 14656967 . 10.1101/gr.1736803 . 403804 . vanc. Rowen L . Aguado B . 3 . Ahearn . ME . Madan . A . Qin . S . Campbell . RD . Hood . L .
• Lehner B . Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region . Genomics . 83 . 1 . 153–67 . 2004 . 14667819 . 10.1016/S0888-7543(03)00235-0 . vanc. Semple JI . Brown SE . 3 . Counsell . Damian . Campbell . R.Duncan . Sanderson . Christopher M .
• Wu YH, Shih SF, Lin JY . Ricin triggers apoptotic morphological changes through caspase-3 cleavage of BAT3 . J. Biol. Chem. . 279 . 18 . 19264–75 . 2004 . 14960581 . 10.1074/jbc.M307049200 . free .
• Lehner B, Sanderson CM . A Protein Interaction Framework for Human mRNA Degradation . Genome Res. . 14 . 7 . 1315–23 . 2004 . 15231747 . 10.1101/gr.2122004 . 442147 .
• Colland F . Functional Proteomics Mapping of a Human Signaling Pathway . Genome Res. . 14 . 7 . 1324–32 . 2004 . 15231748 . 10.1101/gr.2334104 . 442148 . vanc. Jacq X . Trouplin V . 3 . Mougin . C . Groizeleau . C . Hamburger . A . Meil . A . Wojcik . J . Legrain . P .
• Beausoleil SA . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . vanc. Jedrychowski M . Schwartz D . 3 . Elias . JE . Villén . J . Li . J . Cohn . MA . Cantley . LC . Gygi . SP . 2004PNAS..10112130B . free .
• Kumar R, Lutz W, Frank E, Im HJ . Immediate early gene X-1 interacts with proteins that modulate apoptosis . Biochem. Biophys. Res. Commun. . 323 . 4 . 1293–8 . 2004 . 15451437 . 2895269 . 10.1016/j.bbrc.2004.09.006 .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Stelzl U . A human protein-protein interaction network: a resource for annotating the proteome . Cell . 122 . 6 . 957–68 . 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . vanc. Worm U . Lalowski M . 3 . Haenig . Christian . Brembeck . Felix H. . Goehler . Heike . Stroedicke . Martin . Zenkner . Martina . Schoenherr . Anke . 11858/00-001M-0000-0010-8592-0 . 8235923 . free .

Notes and References

1. Banerji J, Sands J, Strominger JL, Spies T . A gene pair from the human major histocompatibility complex encodes large proline-rich proteins with multiple repeated motifs and a single ubiquitin-like domain . Proc Natl Acad Sci U S A . 87 . 6 . 2374–8 . Apr 1990 . 2156268 . 53689 . 10.1073/pnas.87.6.2374 . 1990PNAS...87.2374B . free .
2. Web site: Entrez Gene: BAT3 HLA-B associated transcript 3.