HLA-B73 explained

major histocompatibility complex (human), class I, B73

AllelesB*7301
Structure (See HLA-B)
Symbol(s)HLA-B
EBI-HLAB*7301
Locuschr.6 6p21.31

HLA-B73 (B73) is an HLA-B serotype. The serotype identifies the HLA-B*7301 gene product.[1] Part of B*7301 is similar to the HLA-B22 family, however part resembles the domains seen in other apes.[2] B73 is more common in Western Indian Ocean, Mediterranean and Africa. (For terminology help see: HLA-serotype tutorial)

Serotype

B*73:01 is one of the four B alleles that reacts with neither Bw4 nor Bw6. The others are B*18:06, B*46:01, and B*55:03.[3]

B73 serotype recognition of B*7301 allele-group gene products[4]
B*73 B73Other Sample
allele % % size (N)
7301 22 69 106

B*7301 frequencies

HLA B*7301 frequencies
freq
ref. Population (%)
[5] Parsi (Karachi, Pakistan) 4.9
United Arab Emirates2.0
Italy2.0
Seri (Sonora, Mexico)1.5
Purépecha (Michoacán, Mexico) 1.5
Jews (Israel) (*2 studies)1.2
Beti (Cameroon)1.1
Casablanca (Morocco)0.9
Tbilisi (Georgia)0.9
Mossi (Burkina Faso)0.9
Bulgaria0.9
Sudanese0.8
Tuva (Russia) (2)0.8
Oman0.8
Bamileke (Cameroon)0.6
Pathan (Pakistan)0.5
Khalkha (Mongolia)0.5
Druse Arabs (Israel) 0.5
Baloch (Iran)0.5
Manchester (England)0.5
Algeria (1)0.5
Turkey0.4
Amman (Jordan)0.3
Shona (Harare, Zimbabwe) 0.2
0.2
Nandi (Kenya)0.2
Luo (Kenya)0.2
Campania (Italy)0.2
Greece0.2

Notes and References

  1. 2848993 . 2010 . Marsh . S. G. . Nomenclature for factors of the HLA system, 2010 . Tissue Antigens . 75 . 4 . 291–455 . Albert . E. D. . Bodmer . W. F. . Bontrop . R. E. . Dupont . B. . Erlich . H. A. . Fernández-Viña . M. . Geraghty . D. E. . Holdsworth . R. . Hurley . C. K. . Lau . M. . Lee . K. W. . Mach . B. . Maiers . M. . Mayr . W. R. . Müller . C. R. . Parham . P. . Petersdorf . E. W. . Sasazuki . T. . Strominger . J. L. . Svejgaard . A. . Terasaki . P. I. . Tiercy . J. M. . Trowsdale . J. . 20356336 . 10.1111/j.1399-0039.2010.01466.x .
  2. Hoffmann HJ, Kristensen TJ, Jensen TG, Graugaard B, Lamm LU . Antigenic characteristics and cDNA sequences of HLA-B73 . Eur. J. Immunogenet. . 22 . 3 . 231–40 . 1995 . 8547229 . 10.1111/j.1744-313X.1995.tb00237.x .
  3. Voorter . CE . van der Vlies . S . Kik . M . van den Berg-Loonen . EM . Unexpected Bw4 and Bw6 reactivity patterns in new alleles. . Tissue Antigens . October 2000 . 56 . 4 . 363–70 . 11098937 . 10.1034/j.1399-0039.2000.560409.x .
  4. http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA
  5. Middleton D, Menchaca L, Rood H, Komerofsky R . New allele frequency database . Tissue Antigens . 61 . 5 . 403–7 . 2003 . 12753660 . 10.1034/j.1399-0039.2003.00062.x . free .