HLA-B70 explained
|
| HLA-B (alpha)-β2MG with bound peptide |
major histocompatibility complex (human), class I, B70
|
| Alleles | - 1503, *1509, *1510,
*1518, *1529, *1537
|
| Structure (See HLA-B) |
| Shared data |
| chr.6 6p21.31 | |
HLA-B70 (B70) is an
HLA-
B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.
[1] B70 is one of many split antigens of the broad antigen,
B15.
Serotype
Serotypes B15, B62, B63, B70, B71, B72, B75, B76, B77 recognition of the
HLA B*15 gene products[2] | B*15 | B15 | B62 | B63 | B70 | B71 | B72 | B75 | B76 | B77 | Sample |
| allele | % | % | % | % | % | % | % | % | % | size (N) |
| 1503 | 1 | | | 61 | | 10 | | | | 2569 |
| 1509 | | | | 53 | | | | | | 65 |
| 1510 | 1 | | | 49 | 2 | 2 | 1 | | | 1204 |
| 1518 | | | | 51 | 3 | | | | | 552 |
| 1529 | | | | 19 | | | | | | 21 |
| 1537 | | | | 30 | | | | | | 34 |
| Alleles link-out to IMGT/HLA Databease at EBI | |
Alleles
HLA B*1503 frequencies | | freq |
| ref. | Population | (%) |
| [3] | Burkina Faso Rimaibe | 13.8 |
| Guinea Bissau | 10.8 |
| Cameroon Pygmy Baka | 10.0 |
| South African Natal Zulu | 9.5 |
| Kenya Luo | 8.9 |
| Ivory Coast Akan Adiopodoume | 8.0 |
| Kenya Nandi | 7.9 |
| Cameroon Sawa | 7.7 |
| Zimbabwe Harare Shona | 7.7 |
| USA African America | 7.3 |
| Burkina Faso Fulani | 7.1 |
| Mali Bandiagara | 6.9 |
| Senegal Niokholo Mandenka | 6.9 |
| Cape Verde SE Islands | 6.5 |
| Kenya | 6.3 |
| Uganda Kampala | 6.2 |
| Sudanese | 6.0 |
| Zambia Lusaka | 5.7 |
| Cameroon Yaounde | 4.9 |
| Cape Verde NW Islands | 4.8 |
| Oman | 4.7 |
| Cameroon Bamileke | 4.5 |
| Tunisia Tunis | 4.5 |
| Cameroon Beti | 3.7 |
| Brazil Belo Horizonte | 3.2 |
| Azores Terceira Island | 2.4 |
| Madeira | 2.2 |
| Saudi Arabia Guraiat and Hail | 2.0 |
| Tunisia | 2.0 |
| United Arab Emerates | 1.5 |
| Brazil | 1.4 |
| Cuban White | 1.4 |
| Morocco Nador Metalsa | 1.4 |
| Mexico Mestizos | 1.2 |
| Italy Bergamo | 1.1 |
| Portugal North | 1.1 |
| American Samoa | 1.0 |
| Iran Baloch | 1.0 |
| Mexico Guadalajara Mestizos (2) | 1.0 |
| Azores Central Islands | 0.9 |
| Israel Ashk. and Non-Ashk. Jews | 0.9 |
| Taiwan Hakka | 0.9 |
| Croatia | 0.7 | |
HLA B*1509 frequencies | | freq |
| ref. | Population | (%) |
| Burkina Faso Fulani | 4.1 |
| India West Coast Parsis | 3.0 |
| Spain Eastern Andalusia Gipsy | 3.0 |
| Mexico Mestizos | 2.4 |
| Italy South Campania | 1.2 |
| Burkina Faso Rimaibe | 1.1 |
| China Inner Mongolia | 1.0 |
| Mali Bandiagara | 0.7 |
| Czech Republic | 0.5 | |
HLA B*1510 frequencies | | freq |
| ref. | Population | (%) |
| South African Natal Zulu | 8.5 |
| Zimbabwe Harare Shona | 8.4 |
| Ivory Coast Akan Adiopodoume | 5.7 |
| Kenya | 5.2 |
| Zambia Lusaka | 4.6 |
| Cameroon Sawa | 3.8 |
| Guinea Bissau | 3.8 |
| Kenya Luo | 3.6 |
| Senegal Niokholo Mandenka | 3.2 |
| Cameroon Beti | 2.8 |
| USA African Americans (3) | 2.7 |
| Uganda Kampala | 2.5 |
| Mexico Mestizos | 2.4 |
| Mali Bandiagara | 2.2 |
| Kenya Nandi | 1.7 |
| Brazil Belo Horizonte | 1.6 |
| Cameroon Bamileke | 1.3 |
| Cuban Mulatto | 1.2 |
| Cameroon Yaounde | 1.1 |
| Iran Baloch | 1.0 |
| Sudanese | 1.0 |
| Tunisia | 1.0 |
| Brazil Terena | 0.9 |
| Cape Verde NW Islands | 0.8 |
| United Arab Emerates | 0.8 |
| USA North American Natives | 0.8 |
| Guadalajara Mestizos (2) | 0.5 | |
HLA B*1518 frequencies | | freq |
| ref. | Population | (%) |
| South Africa Natal Tamil | 4.1 |
| Autonomous Tibetans | 3.8 |
| India Mumbai Marathas | 3.7 |
| China North Han | 2.9 |
| USA Hawaii Okinawa | 2.9 |
| China Guangzhou Han | 2.4 |
| India Andhra Pradesh Golla | 2.4 |
| China Beijing | 2.3 |
| Taiwan Hakka | 1.8 |
| Japan | 1.7 |
| India North Delhi | 1.6 |
| China Inner Mongolia | 1.5 |
| China Qinghai Hui | 1.4 |
| Czech Republic | 1.4 |
| China Yunnan Nu | 1.3 |
| Shijiazhuang Tianjian Han | 1.1 |
| Ivory Coast Akan Adiopodoume | 1.1 |
| Senegal Niokholo Mandenka | 1.1 |
| Zambia Lusaka | 1.1 |
| Portugal Centre | 1.0 |
| Singapore Javanese Indonesians | 1.0 |
| Thailand (3) | 1.0 |
| South Korea (3) | 0.9 |
| Cape Verde Islands | 0.8 |
| France South East | 0.8 |
| Guinea Bissau | 0.8 |
| China South Han | 0.7 |
| China Yunnan Lisu | 0.7 |
| Russia Tuva (2) | 0.6 |
| Singapore Chinese Han | 0.6 |
| Spain Eastern Andalusia | 0.6 | |
Notes and References
- 2848993 . 2010 . Marsh . S. G. . Nomenclature for factors of the HLA system, 2010 . Tissue Antigens . 75 . 4 . 291–455 . Albert . E. D. . Bodmer . W. F. . Bontrop . R. E. . Dupont . B. . Erlich . H. A. . Fernández-Viña . M. . Geraghty . D. E. . Holdsworth . R. . Hurley . C. K. . Lau . M. . Lee . K. W. . Mach . B. . Maiers . M. . Mayr . W. R. . Müller . C. R. . Parham . P. . Petersdorf . E. W. . Sasazuki . T. . Strominger . J. L. . Svejgaard . A. . Terasaki . P. I. . Tiercy . J. M. . Trowsdale . J. . 20356336 . 10.1111/j.1399-0039.2010.01466.x .
- http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA
- Middleton D, Menchaca L, Rood H, Komerofsky R . New allele frequency database . Tissue Antigens . 61 . 5 . 403–7 . 2003 . 12753660 . 10.1034/j.1399-0039.2003.00062.x . free .
