HLA-B67 explained

major histocompatibility complex (human), class I, B67

AllelesB*6701
Structure (See HLA-B)
Symbol(s)HLA-B
EBI-HLAB*6701
Locuschr.6 6p21.31

HLA-B67 (B67) is an HLA-B serotype. The serotype identifies the more common HLA-B*67 gene products.[1] B67 is region specific recombinant haplotype formed by the gene conversion of B*39, an allele common along the Northwest Pacific Rim (Taiwan, Japan, Korea, Coastal Siberia), and B7, B22, or B27.[2] (For terminology help see: HLA-serotype tutorial)

Serotype

B67 Serotype recognition of the B*67 allele-group gene products[3]
B*67B67Other Sample
allele % % size (N)
6701 32 62 81

By allele

HLA B*6701 frequencies
freq
ref. Population (%)
[4] Osaka Region (Japan)2.6
Hakka (Taiwan)1.8
Japan (5)1.7
Harbin Man (China) 1.7
Beijing (China)1.5
Linqu (Shandong, China)1.1
Siraya (Taiwan)1.0
Portugal South1.0
Oold (Mongolia)1.0
American Samoa1.0
Pazeh (Taiwan)0.9
South Korea (3)0.9
N. Korean (Harbin,China)0.8
Arratia Basque (Spain)0.6
Tarialan Khoton (Mongolia) 0.6
Shanghai (China) 0.6
Natal Zulu (South African)0.5
Yunnan Han (China)0.5
Turkey0.4
Southern Han (China)0.4
Tuva (Russia)0.3
Chinese (Hong Kong, China)0.1

Notes and References

  1. 2848993 . 2010 . Marsh . S. G. . Nomenclature for factors of the HLA system, 2010 . Tissue Antigens . 75 . 4 . 291–455 . Albert . E. D. . Bodmer . W. F. . Bontrop . R. E. . Dupont . B. . Erlich . H. A. . Fernández-Viña . M. . Geraghty . D. E. . Holdsworth . R. . Hurley . C. K. . Lau . M. . Lee . K. W. . Mach . B. . Maiers . M. . Mayr . W. R. . Müller . C. R. . Parham . P. . Petersdorf . E. W. . Sasazuki . T. . Strominger . J. L. . Svejgaard . A. . Terasaki . P. I. . Tiercy . J. M. . Trowsdale . J. . 20356336 . 10.1111/j.1399-0039.2010.01466.x .
  2. Little AM, Domena JD, Hildebrand WH, etal . HLA-B67: a member of the HLA-B16 family that expresses the ME1 epitope . Tissue Antigens . 43 . 1 . 38–43 . 1994 . 7517584 . 10.1111/j.1399-0039.1994.tb02294.x .
  3. http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA
  4. Middleton D, Menchaca L, Rood H, Komerofsky R . New allele frequency database . Tissue Antigens . 61 . 5 . 403–7 . 2003 . 12753660 . 10.1034/j.1399-0039.2003.00062.x . free .