HLA-B58 explained
|
| HLA-B (alpha)-β2MG with bound peptide |
major histocompatibility complex (human), class I, B58
|
| Alleles |
|
| Structure (See HLA-B) |
| Shared data |
| Locus | chr.6 6p21.31 | |
HLA-B58 (B58) is an
HLA-
B serotype. B58 is a split antigen from the
B17 broad antigen, the sister serotype
B57.
[1] The serotype identifies the more common HLA-B*58 gene products.
[2] (For terminology help see: HLA-serotype tutorial) B*5801 is associated with
allopurinol induced inflammatory necrotic skin disease.
Serotype
B58 and B17 serotype recognition of some more common HLA B*58 alleles[3] | B*58 | B58 | B17 | Sample |
| allele | % | % | size (N) |
| 5801 | 79 | 4 | 2096 |
| 5802 | 72 | 3 | 837 | |
Allele distribution
HLA B*5801 frequencies | | freq |
| ref. | Population | (%) |
| [4] | Cameroon Pygmy Baka | 15.0 |
| India Khandesh Pawra | 15.0 |
| Cameroon Sawa | 11.5 |
| Taiwan Hakka | 10.9 |
| Kenya Nandi | 10.0 |
| India West Bhils | 9.0 |
| China South Han | 8.9 |
| China Inner Mongolia | 8.8 |
| India North Delhi | 8.8 |
| Thailand Northeast | 8.4 |
| Guinea Bissau | 7.8 |
| Thailand | 7.7 |
| India Mumbai Marathas | 7.4 |
| India Andhra Pradesh Golla | 7.2 |
| Kenya Luo | 7.0 |
| Senegal Niokholo Mandenka | 6.9 |
| India New Delhi | 6.8 |
| Oman | 6.8 |
| Russia Tuva (2) | 6.7 |
| South Korea (3) | 6.5 |
| Italy Sardinia (3) | 6.4 |
| Burkina Faso Fulani | 6.1 |
| Taiwan Siraya | 5.9 |
| India North Hindus | 5.8 |
| Burkina Faso Mossi | 5.7 |
| Cameroon Yaounde | 5.4 |
| Cameroon Bamileke | 5.2 |
| Singapore Riau Malay | 5.0 |
| Saudi Arabia Guraiat and Hail | 4.6 |
| France Corsica | 4.5 |
| Sudanese | 4.5 |
| Zimbabwe Harare Shona | 4.4 |
| Burkina Faso Rimaibe | 4.3 |
| Iran Baloch | 4.0 |
| South African Natal Zulu | 4.0 |
| Tunisia | 4.0 |
| Uganda Kampala | 4.0 |
| Cameroon Beti | 3.7 |
| Tunisia Ghannouch | 3.7 |
| Taiwan Pazeh | 3.6 |
| Tunisia Tunis | 3.4 |
| Italy North (1) | 3.3 |
| Israel Ashkenazi and Non Ashkenazi Jews | 3.2 |
| India West Coast Parsis | 3.0 |
| China North Han | 2.9 |
| Ivory Coast Akan Adiopodoume | 2.3 |
| Mali Bandiagara | 2.2 |
| Mexico Zaptotec Oaxaca | 2.2 |
| South Africa Natal Tamil | 2.0 |
| China Yunnan Nu | 1.9 |
| Bulgaria | 1.8 |
| China Tibet Autonomous Region Tibetans | 1.6 |
| France South East | 1.6 |
| Israel Arab Druse | 1.5 |
| Czech Republic | 1.4 |
| Georgia Tbilisi Georgians | 1.4 |
| Jordan Amman | 1.4 |
| Morocco Nador Metalsa (berber) | 1.4 |
| Croatia | 1.3 |
| Romanian | 1.3 |
| Spain Eastern Andalusia | 1.2 |
| Australian Aborigine Cape York Peninsula | 1.0 |
| B*5802 |
| Cameroon Bamileke | 14.3 |
| Kenya Luo | 12.5 |
| Cameroon Yaounde | 10.9 |
| Cameroon Pygmy Baka | 10.0 |
| Cameroon Beti | 9.8 |
| Kenya Nandi | 8.5 |
| South African Natal Zulu | 8.5 |
| Cameroon Sawa | 7.7 |
| Zimbabwe Harare Shona | 6.4 |
| Cape Verde Northwestern Islands | 5.6 |
| Uganda Kampala | 4.4 |
| Central Africa Republic Mbenzele Pygmy | 4.0 |
| Zambia Lusaka | 2.3 |
| Iran Baloch | 1.0 |
| Tunisia | 1.0 | |
Disease
HLA-B*5801 is involved in allopurinol sensitive drug induced Stevens–Johnson syndrome.[5] [6] Allopurinol is a frequent cause of severe cutaneous adverse reactions, including drug-hypersensitivity syndrome, Stevens–Johnson syndrome, and toxic epidermal necrolysis (SJS/TEN).[7] The association with allopurinol sensitivity in SJS/TEN was extremely strong in Asia, and somewhat less associated in Europeans.[8]
Notes and References
- Ways JP, Coppin HL, Parham P . The complete primary structure of HLA-Bw58 . J. Biol. Chem. . 260 . 22 . 11924–33 . 1985 . 10.1016/S0021-9258(17)38967-6 . 2995352 . free .
- 2848993 . 2010 . Marsh . S. G. . Nomenclature for factors of the HLA system, 2010 . Tissue Antigens . 75 . 4 . 291–455 . Albert . E. D. . Bodmer . W. F. . Bontrop . R. E. . Dupont . B. . Erlich . H. A. . Fernández-Viña . M. . Geraghty . D. E. . Holdsworth . R. . Hurley . C. K. . Lau . M. . Lee . K. W. . Mach . B. . Maiers . M. . Mayr . W. R. . Müller . C. R. . Parham . P. . Petersdorf . E. W. . Sasazuki . T. . Strominger . J. L. . Svejgaard . A. . Terasaki . P. I. . Tiercy . J. M. . Trowsdale . J. . 20356336 . 10.1111/j.1399-0039.2010.01466.x .
- http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA
- Middleton D, Menchaca L, Rood H, Komerofsky R . New allele frequency database . Tissue Antigens . 61 . 5 . 403–7 . 2003 . 12753660 . 10.1034/j.1399-0039.2003.00062.x . free .
- Chung WH, Hung SI, Chen YT . Human leukocyte antigens and drug hypersensitivity . Curr Opin Allergy Clin Immunol . 7 . 4 . 317–23 . August 2007 . 17620823 . 10.1097/ACI.0b013e3282370c5f . 31415054 .
- Tassaneeyakul W, Jantararoungtong T, Chen P, Lin PY, Tiamkao S, Khunarkornsiri U, Chucherd P, Konyoung P, Vannaprasaht S, Choonhakarn C, Pisuttimarn P, Sangviroon A, Tassaneeyakul W . Strong association between HLA-B*5801 and allopurinol-induced Stevens–Johnson syndrome and toxic epidermal necrolysis in a Thai population . Pharmacogenet Genomics . 2009 . 704–9 . 9 . 19 . 19696695 . 10.1097/FPC.0b013e328330a3b8 . 24941838 .
- Hung SI . HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol . Proc. Natl. Acad. Sci. U.S.A. . 102 . 11 . 4134–9 . March 2005 . 15743917 . 554812 . 10.1073/pnas.0409500102 . vanc. Chung WH . Liou LB . 3 . Chu . CC . Lin . M . Huang . HP . Lin . YL . Lan . JL . Yang . LC. 2005PNAS..102.4134H . free .
- Lonjou C . A European study of HLA-B in Stevens–Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs . Pharmacogenet. Genomics . 18 . 2 . 99–107 . February 2008 . 18192896 . 10.1097/FPC.0b013e3282f3ef9c . vanc. Borot N . Sekula P . 3 . Ledger . Neil . Thomas . Laure . Halevy . Sima . Naldi . Luigi . Bouwes-Bavinck . Jan-Nico . Sidoroff . Alexis. 35512622 .
