HLA-B56 explained

major histocompatibility complex (human), class I, B56

AllelesB*5601, *5602, *5603, *5604
Structure (See HLA-B)
Symbol(s)HLA-B
EBI-HLAB*5601
B*5602
B*5603
B*5604
Locuschr.6 6p21.31

HLA-B56 (B56) is an HLA-B serotype. B56 is a split antigen from the B22 broad antigen, sister serotypes are B54 and B55. The serotype identifies the more common HLA-B*56 gene products.[1] (For terminology help see: HLA-serotype tutorial)

Serotype

B56 and B22 serotype recognition of Some HLA B*56 allele-group gene products[2]
B*56 B56B22 Sample
allele % % size (N)
5601 72 5 671
5603 46 8 13
5604 73 11

Allele distribution

HLA B*5601 frequencies
freq
ref. Population (%)
[3] Australian Aborigine Kimberly35.5
Papua New Guinea Madang34.6
Papua New Guinea New Britain Rabaul31.6
Taiwan Ami20.4
New Caledonia19.2
Australian Aborigine Groote Eylandt18.0
Australian Aborigine Cape York Peninsula16.5
Australian Aborigine Yuendumu11.4
China Yunnan Lisu9.4
China Yunnan Nu3.8
Senegal Niokholo Mandenka2.7
Sudanese2.5
American Samoa2.0
China Guangxi Maonan1.9
Taiwan Hakka1.8
Thailand1.8
Finland1.7
Georgia Tbilisi Kurds1.7
India Andhra Pradesh Golla1.4
Croatia1.3
Japan (5)1.3
South Africa Natal Tamil1.0
Taiwan Rukai1.0

Notes and References

  1. 2848993 . 2010 . Marsh . S. G. . Nomenclature for factors of the HLA system, 2010 . . 75 . 4 . 291–455 . Albert . E. D. . Bodmer . W. F. . Bontrop . R. E. . Dupont . B. . Erlich . H. A. . Fernández-Viña . M. . Geraghty . D. E. . Holdsworth . R. . Hurley . C. K. . Lau . M. . Lee . K. W. . Mach . B. . Maiers . M. . Mayr . W. R. . Müller . C. R. . Parham . P. . Petersdorf . E. W. . Sasazuki . T. . Strominger . J. L. . Svejgaard . A. . Terasaki . P. I. . Tiercy . J. M. . Trowsdale . J. . 20356336 . 10.1111/j.1399-0039.2010.01466.x .
  2. http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA
  3. Middleton . D. . Menchaca . L. . Rood . H. . Komerofsky . R. . New allele frequency database: http://www.allelefrequencies.net . . 61 . 5 . 403–407 . 2003 . 12753660 . 10.1034/j.1399-0039.2003.00062.x. free .