major histocompatibility complex (human), class I, B53 | ||
| Alleles | B*5301 B*5302 | |
| Structure (See HLA-B) | ||
| Symbol(s) | HLA-B | |
| EBI-HLA | B*5301 | |
| EBI-HLA | B*5302 | |
| Locus | chr.6 6p21.31 | |
HLA-B53 (B53) is an HLA-B serotype. The serotype identifies the more common HLA-B*53 gene products.[1] The B53 sequence is identical to B35 but short sequence specifies a Bw4 rather than a Bw6 motif (as found in B35), indicating B53 is a recent product of gene conversion.[2] This suggests an origin for HLA-B53 involving a gene conversion of HLA-B35 by an allele containing this Bw4 sequence. (For terminology help see: HLA-serotype tutorial)
| B*53 | B53 | B35 | Sample | |
| allele | % | % | size (N) | |
| 5301 | 86 | 5 | 3054 | |
| 5302 | 80 | 20 | 5 |
| freq | |||
| ref. | Population | (%) | |
| [4] | Akan Adiopodoume (Ivory Coast) | 22.7 | |
| Rimaibe (Burkina Faso) | 22.3 | ||
| Mossi (Burkina Faso) | 20.8 | ||
| Bandiagara (Mali) | 15.9 | ||
| Sawa (Cameroon) | 11.5 | ||
| Lusaka (Zambia) | 10.2 | ||
| Baka Pygmy (Cameroon) | 10.0 | ||
| Guinea Bissau | 10.0 | ||
| Harare Shona (Zimbabwe) | 9.3 | ||
| Baloch (Iran) | 9.1 | ||
| Kenya | 8.7 | ||
| Canoncito Navajo (USA) | 8.5 | ||
| Brahui (Pakistan) | 7.7 | ||
| Niokholo Mandenka (Senegal) | 5.3 | ||
| Croatia (2) | 5.0 | ||
| Mongolia Khoton Tarialan | 4.9 | ||
| Pakistan Baloch | 4.6 | ||
| Casablanca (Morocco) | 3.7 | ||
| Arratia Basque (Spain) | 3.3 | ||
| Crete (Greece) | 3.2 | ||
| Israel Arab Druse | 2.5 | ||
| Israel Gaza Palestinians | 2.4 | ||
| Amman (Jordan) | 2.4 | ||
| Tunis (Tunisia) | 2.3 | ||
| Tuva (2) (Russia) | 2.2 | ||
| Oman | 2.1 | ||
| France South East | 1.6 | ||
| Saudi Arabia Guraiat and Hail | 1.5 | ||
| Berber (Morocco) | 1.4 | ||
| Georgia Svaneti Svans | 1.3 | ||
| Mongolia Khalkh Ulaanbaatar | 1.2 | ||
| Spain Catalonia Girona | 1.1 | ||
| India Andhra Pradesh Golla | 1.0 | ||
| Mongolia Khalha | 1.0 |
| freq | |||
| ref. | Population | (%) | |
| Zimbabwe | 3.6 | ||
| Zambia Lusaka | 2.3 | ||
| N. Afr. Negroid | 2.1 | ||
| Kenya Luo | 1.9 | ||
| Cameroon Yaounde | 1.7 | ||
| [5] | African American | 1.5 | |
| Kenya Nandi | 1.3 | ||
| American Hispanic | 0.2 | ||
| ' | |||
| A*6802 : Cw*0401 : B*5301 | |||
| Mali Bandihagara | 2.7 | ||
| African American | 1.4 | ||
| Kenya Nandi | 1.0 | ||
| Hispanic American | 0.6 | ||
| Caucasian American | 0.2 | ||
Despite its low frequency, the A36-Cw4-B53 haplotype is one of the most common A-Cw-B haplotypes, as it is the 4th most common in African Americans.