| B*5101-β2MG with bound peptide | ||
major histocompatibility complex (human), class I, B52 | ||
| Alleles | B*5201, 5202, 5203, . . . | |
| Structure (See HLA-B) | ||
| Shared data | ||
| chr.6 6p21.31 | ||
B52 is a split antigen of the broad antigen B5, and is a sister type of B51. B*5201 likely formed as a result of a gene conversion event between another HLA-B allele and HLA-B*5101.[2] There are a number of alleles within the B*52 allele group.[3]
| B*52 | B52 | B5 | B51 | B53 | Sample | |
| allele | % | % | % | % | size (N) | |
| 5201 | 84 | 2 | 7 | 1 | 2823 | |
| Alleles link-out to IMGT/HLA Databease at EBI | ||||||
| freq | |||
| ref. | Population | (%) | |
| [5] | China Yunnan Lisu | 21.7 | |
| China Yunnan Nu | 18.6 | ||
| Bulgaria Gipsy | 18.2 | ||
| Venezuela Sierra de Perija Yucpa | 12.8 | ||
| India Andhra Pradesh Golla | 12.0 | ||
| Japan Central | 10.7 | ||
| Japan | 10.4 | ||
| Georgia Tbilisi Kurds | 10.3 | ||
| Mali Bandiagara | 8.3 | ||
| South Africa Natal Tamil | 8.2 | ||
| Israel Ashk. and Non-Ashk. Jews | 7.3 | ||
| India North Hindus | 6.7 | ||
| China Beijing | 6.1 | ||
| India New Delhi | 6.1 | ||
| India Mumbai Marathas | 5.6 | ||
| Tunisia Ghannouch | 5.5 | ||
| Thailand pop3 | 5.1 | ||
| India West Coast Parsis | 5.0 | ||
| India North Delhi | 4.9 | ||
| Mexico Mestizos | 4.9 | ||
| Argentina Toba Rosario | 4.7 | ||
| Mexico Zaptotec Oaxaca | 4.5 | ||
| USA Hispanic | 4.5 | ||
| China Qinghai Hui | 4.1 | ||
| China Inner Mongolia | 3.9 | ||
| China North Han | 3.8 | ||
| Oman | 3.8 | ||
| Senegal Niokholo Mandenka | 3.7 | ||
| Bulgaria | 3.6 | ||
| Thailand | 3.5 | ||
| Ivory Coast Akan Adiopodoume | 3.4 | ||
| Venezuela Perja Mountain Bari | 3.4 | ||
| Italy North pop 1 | 3.3 | ||
| Sudanese | 3.3 | ||
| Romanian | 3.2 | ||
| Singapore Riau Malay | 3.0 | ||
| Autonomous Region Tibetans | 2.8 | ||
| Russia Tuva pop 2 | 2.8 | ||
| South Korea pop 3 | 2.8 | ||
| Iran Baloch | 2.5 | ||
| Tunisia | 2.5 | ||
| Jordan Amman | 2.4 | ||
| USA Hawaii Okinawa | 2.4 | ||
| Singapore Javanese Indonesians | 2.0 | ||
| Spain Eastern Andalusia | 1.8 | ||
| Macedonia pop 4 | 1.6 | ||
| Uganda Kampala | 1.6 | ||
| Belgium | 1.5 | ||
| Mexico Guadalajara Mestizos pop2 | 1.5 | ||
| Singapore Thai | 1.5 | ||
| Brazil | 1.4 | ||
| China Yunnan Lisu | 1.4 | ||
| Azores Santa Maria and Sao Miguel | 1.3 | ||
| France South East | 1.2 | ||
| Italy North Pavia | 1.2 | ||
| Saudi Arabia Guraiat and Hail | 1.2 | ||
| Mexico Chihuahua State Tarahumara | 1.1 | ||
| Tunisia Tunis | 1.1 | ||
| Israel Arab Druse | 1.0 | ||
| Japan Ainu Hokkaido | 1.0 | ||
| Portugal Centre | 1.0 | ||
| Singapore Chinese | 1.0 | ||
| Taiwan Minnan pop 1 | 1.0 | ||
| USA Caucasian | 1.0 | ||
| Azores Central Islands | 0.9 | ||
| China South Han | 0.9 | ||
| Macedonia pop 4 | 0.7 | ||
| Morocco Nador Metalsa Class I | 0.7 | ||
| Georgia Svaneti Svans | 0.6 | ||
| Ireland South | 0.6 | ||
| Italy Bergamo | 0.6 |
There are 18 alleles, with 14 amino acid sequence variants in B52. Of these only 9 are frequent enough to have been reliably serotyped. B*5201 is the most common, but others have a large regional abundance.
HLA-B52 appears to have the strongest linkage to ulcerative colitis in Japan.[6] [7] This form of disease is frequently found with Takayasu's arteritis.
Takayasu's arteritis appears to have an independent link to B52 associated disease.[8] [9] The association with B*5201 increases risk of pulmonary infarction, ischemic heart disease, aortic regurgitation, systemic hypertension, renal artery stenosis, cerebrovascular disease, and visual disturbance.[10]